All posts by atascientific

What is Warm Chain Logistics?

September 18, 2025Newslettersatascientific

Cold Chain logistics have been great for food transport globally, but it isn’t cool for cells. Let’s break a paradigm, why not?

For years there have been incremental developments in cryopreservation for cell transport, many to research a better cryoprotectant so your cells may survive the dreaded defrost. It is well documented that every cell seems to have a favoured regime – such knowledge is from countless cell deaths. How many of us do this because it is what we have learnt or ignorant of what is possible? How much money has been lost on shipping cells frozen? Cells arrive dead and your supplier states… “too bad… so sad…” What about those priceless cells? Shipping them frozen must feel like Russian Roulette!

Enough is enough – for the love of your cells, stop this madness!

What is Warm Chain Logistics?

Warm Chain Logistics is a far cleverer approach. This is made possible with the CellBox from Cellbox Solutions in Germany. This incredible system is a portable CO2 incubator that can be configured for ground transport or even flight, all the while keeping the precious cargo at 37 Deg C and 5 % CO2. The cells arrive happy, healthy and ready to use immediately. Most grow better in the Cellbox compared to staying still in the lab incubator!

There are two versions. The Shipper and the GO, each offer the option as a Ground or Flight transport system including all the regulatory approvals. Long distance is best with Shipper, whilst many are loving the CellBox Go due to its light weight & flexibility to be carried as a backpack.

Not just a shipper. In Australia, distances are vast, research happens in the field – how do you maintain cell viability and survival when you are working to the left of the middle of nowhere?

Cellbox is ideal., and you can transport them back without freezing them. The artificial insemination industry could be transformed with this technology. Ok, many of us are city centric – what about taking your cells to your microscopy facility? Hours of imaging whilst your cells freeze their bits off on the bench! Have you considered using Cellbox, your personal incubator, sitting happily with you and then carrying it back to your lab.

Next time you ask AI ‘How can I transport my cells?’ think Warm Chain Logistics and ask us for a demo of the CellBox. This technology has transformed lives here in Australia already, shipping Neuronal cells, across Sydney, running patient derived cells in QLD for clinical trials, helping access for patients in North Queensland who cannot travel but the CellBox could. It has even helped marine research in Ningaloo.

Want to join the revolution? Give us a call or send us an email.. lets see Cellbox flip the script for your cells, you know they’ll love you for it!

World First — Clever Engineering and Flexible Technology Solves a Nanoparticle Challenge

September 8, 2025Newslettersatascientific

Original post: World First ;Clever Engineering and Flexible Technology Solves a Nanoparticle Challenge

It is not every day that you get to solve a unique problem. But that’s exactly what happened when a collaboration with researchers at the University of Melbourne led to a world first breakthrough in scalable Metal Phenolic Network (MPN) nanoparticle production.

About a year ago at the 14th Nanomedicines Conference on Sydney Harbour, I was one of the fortunate people to witness the presentation by Prof Frank Caruso of Chemical Engineering, Melbourne University, describing the effectiveness of Metal Phenolic Networks (MPNs) to target specific organs. This science is extraordinary given it has the potential to create organ specific nanoparticles for drug delivery.

However, translating this science into scalable production posed significant hurdles. The method can be very labour intensive, and particularly difficult to automate as there are multiple order and time sensitive components required.

Engineering meets chemistry

During discussions with postdoctoral researchers Dr Christina Cortez-Jugo and Dr Qingqing Fan, it became clear that existing off the shelf technologies that have been developed for LNPs couldn’t easily handle the unique requirements of newer MPN formulations. Specifically, the requirement to sequentially introduce multiple distinct components with precisely controlled timing and order presented a challenge not addressed by current commercial technologies.

Micropore Technologies have already solved many issues of scaling complex chemistries in the past. ATA Scientific created a test rig with the Pathfinder system and some very cool modifications at our disposal. Theories around flow dynamics and introduction speed were numerous, and at times perplexing. In practice, with the help of Dr Jingqu (Rachel) Chen we simply set up our best estimate to see if we could even make the nanoparticles. Post processing and subsequent analysis on the Malvern Panalytical Zetasizer Ultra Red proved we had extraordinary success!

Scalable reality

An experiment plan followed, to demonstrate the scalability of MPN NPs using Pathfinder. The following was proposed:

Batch comparison: Produce both manual and Pathfinder-fabricated MPN NPs using 2–3 well-reported formulations with varying components. These will be scaled at 2 mL, 5 mL, 10 mL, 50 mL, and 100 mL volumes, with comparison of size, zeta potential, encapsulation efficiency, and in vivo performance across batches.
Functional testing: Preparation of larger-scale batches of MPN nanoparticles loaded with various therapeutic small molecule drugs using the Pathfinder system to evaluate functional performance. Results will be benchmarked against manually synthesized nanoparticles using identical analytical parameters.

Why does this matter?

Without scalable and reproducible production, the entire MPN project could have remained stuck in the lab. It is now clear that the flexibility of the Micropore Technologies Pathfinder uniquely resolves this challenge — not just at lab scale, but full GMP production is clearly possible given this technology is used to create litres/minute, opening the opportunities for treatments with the MPN technology.

What’s next?

Buoyed by the preliminary results, the team have submitted an abstract to the A-RNA25 conference in September this year entitled “Bioactive metal-organic nanoparticles: a versatile platform for RNA delivery”. This is a presentation not to be missed — visit www.a-rnameeting.org.au for more details.

For more information on how the Pathfinder may solve your nanoparticle needs, contact Pete Davis, ATA Scientific +61 0417 778 971 or email pdavis@atascientific.com.au

How to Measure Surface Tension for High-Performance Battery Manufacturing

August 19, 2025Material Science - GuideSurface Tension Measurement, tensiometeratascientific

Surface tension measurement in batteries refers to analysing how liquids such as electrode slurries and electrolytes interact with solid surfaces like electrodes, separators, and casings. It’s a critical factor in manufacturing and R&D because it governs wetting, coating uniformity, adhesion, and material compatibility.

In this guide, we will share the essential methods for measuring surface tension and delve into its crucial role in advancing battery manufacturing and performance.

This guide will help you:

Understand why surface tension is important for battery manufacturing and research
Learn the main methods for measuring surface tension in liquids and solids
Match each method to the right KRÜSS instrument for your application
See how surface tension measurement fits into battery R&D and quality control workflows

By the end, you’ll know which technique to use, when to use it, and how it supports consistent, reliable battery production.

What is Surface Tension?

Surface tension, interfacial tension, and surface free energy (SFE) are closely related properties in surface and colloid science. Surface tension is the cohesive energy at a liquid’s interface, while interfacial tension describes the same phenomenon between two immiscible liquids or a liquid and a solid.

SFE refers to the energy stored at a solid’s surface from disrupted molecular bonds, high-SFE materials like metals, glass, and ceramics wet easily, whereas low-SFE materials such as PTFE or polypropylene resist wetting and are harder to coat or bond.

The Critical Role of Surface Tension in Battery Manufacturing & Research

Surface tension plays a critical role in battery manufacturing as it has a direct impact on the quality of the coating and material wetting which affect the overall cell performance.

Electrode Slurry and Coating: Slurries of active materials, binders, and solvents must wet copper or aluminium foils evenly. If surface tension is too high or too low, coatings can bead or form uneven layers, leading to defects and performance loss.

Electrolyte Wetting: Electrolytes must fully penetrate porous electrodes and separators for efficient ion transport. Poor wetting from a surface tension mismatch can cause dry spots, reduced capacity, and safety risks. Lower surface tension generally speeds wetting.

Performance and Safety: Surface tension impacts slurry dispersion stability, affecting how well nanoparticles and additives are distributed. Good control improves energy density, safety, and reliability.

Aqueous Processing: Moving to water-based slurries instead of toxic solvents like NMP makes surface tension control even more critical.

In short, surface tension is fundamental for achieving reliable wetting, uniform coatings, strong adhesion, and consistent material distribution, essential for high-performance, long-lasting batteries.

Key Methods for Surface Tension Measurement

Surface tension is typically measured by observing how a liquid behaves at its interface (usually with air) using methods based on mechanical force or optical analysis.

Force Tensiometry

Du Noüy Ring Method: A platinum ring is submerged in the liquid and slowly pulled upward. The force needed to detach the ring is proportional to the surface tension.
Wilhelmy Plate Method: A thin, flat plate (usually platinum) is partially immersed, and the force acting on the plate is used to calculate surface tension.

Example instrument: The KRÜSS Tensiio Force Tensiometer provides automated, precise, and reproducible measurements for liquids and solids. With an optional high-resolution camera, it can record the contact area at the liquid surface, enabling simultaneous optical drop analysis and adhesion measurement.

Optical Tensiometry:

Pendant Drop: A liquid drop is suspended from a needle and its curvature is analysed via the Young–Laplace equation.

Sessile Drop / Contact Angle: Measures the angle where a liquid, solid, and gas meet, providing insight into wettability, adhesion, and surface free energy (SFE). This is commonly performed using a Goniometer/tensiometer method, which allows precise measurement of contact angles and droplet shapes for both research and quality control applications.

Example instrument: The KRÜSS DSA100 Drop Shape Analyser measures contact angle, surface tension, and interfacial tension with high-speed cameras and advanced software. It’s ideal for optimising electrode and separator wetting, checking electrolyte compatibility, ensuring slurry coating homogeneity, and supporting QC.

Learn more about the Goniometer/tensiometer method.

Bubble Pressure Tensiometry:

A bubble forms at the end of a submerged capillary, and the pressure needed to form it reflects the surface tension at that moment. This method measures dynamic surface tension over milliseconds to seconds, valuable for electrolytes or slurries containing surfactants, dispersants, or binders.

Example instrument: The KRÜSS BPT Mobile Bubble Pressure Tensiometer captures surface tension changes in real time for rapidly changing formulations. The pressure needed to form each bubble reflects the surface tension at that exact moment. This is especially useful for formulations that change over milliseconds to seconds, such as those containing surfactants, dispersants, or binders.

Spinning Drop Tensiometer

The Spinning Drop Tensiometer is specialised for ultra-low interfacial tension, commonly used in emulsion studies. It is increasingly relevant to advanced battery systems with ionic liquids, complex liquid–liquid interfaces, and multiphase electrolytes.

Dynamic Foam Analyser

Measures foam formation, stability, and drainage—important in slurry preparation, coating, and electrolyte mixing, where unwanted foaming can cause defects.

Example instrument: The KRÜSS DFA100 evaluates foaming behaviour and anti-foaming strategies for more consistent manufacturing.

Portable contact angle instrument

Hand-held devices like the KRÜSS Mobile Surface Analyser (MSA) provide fast, on-site wettability and cleanliness checks—ideal for QC, surface preparation, and coating processes in battery production.

Matching Measurement Methods to Specific Instruments

Choosing the right analytical technology depends on the type of surface or interfacial measurement you need. Whether you’re studying wetting behaviour, optimising formulations, or characterising material interfaces, KRÜSS offers a range of precise instruments tailored to specific applications.

The table below matches measurement methods to the most appropriate KRÜSS tensiometers, helping you select the best system for your needs.

Method	What it measures	Best For	Advantages	Recommended Instrument
Du Noüy Ring	Static surface/ interfacial tension using a platinum ring	Quality control of surfactant or coating liquids	Simple, industry-standard (ASTM D 971 and IEC 62961)	KRUSS Force Tensiometer K20 (Compact, entry-level tensiometer for routine QC) Tensiio (Automated, high precision tensiometer with optional optical camera)
Wilhelmy Plate	Static surface tension, contact angle, wetting force using a thin plate	Solid–liquid wetting, adhesion testing, surface treatment	High precision, fast	KRÜSS Force Tensiometer K20 Tensiio
Pendant Drop	Surface/interfacial tension (static) using shape analysis of a hanging droplet (Young–Laplace fit)	Electrolyte–air or oil–water systems	High accuracy, low sample volume, temperature and atmosphere control	KRÜSS Drop Shape Analyser DSA100 (Automated, high precision, modular system ideal for challenging surfaces) DSA 30 (Ideal for labs needing reliable measurements with some flexibility, without full automation or advanced modules) DSA 25 (Great for teaching labs, routine quality checks, or first-step research projects with budget constraints)
Sessile Drop / Contact Angle	Static contact angle, surface free energy (SFE) using a drop placed on solid to assess wetting & adhesion	Wetting, surface treatment, coatings, battery electrode & separator surfaces	Wetting and adhesion data together	KRÜSS Drop Shape Analyser DSA100  DSA 30 DSA 25
Bubble Pressure	Dynamic surface tension using the maximum pressure to form a gas bubble in liquid	Surfactant screening, slurry formulation, battery slurries	Millisecond time resolution	KRÜSS Bubble Pressure Tensiometer BP100

Integrating Surface Tension Measurement into Battery R&D and QC

From lithium-ion to solid-state and sodium-ion, battery technology is advancing rapidly, but one principle applies to them all: consistent interaction between materials drives performance. Achieving optimal wettability of electrodes and separators by the electrolyte boosts capacity, safety, and lifespan.

By integrating surface tension measurement into both R&D and QC, manufacturers can prevent costly defects and ensure product consistency from the lab to the production line. Learn more about integrating analytical techniques into battery recycling.

Holistic approach: Combine force tensiometry for electrolyte behaviour with contact angle measurements for electrode surfaces to gain a complete interfacial profile.
From lab to line: Apply these measurements to verify slurry stability, electrolyte compatibility, and coating quality at every stage.
Future-ready automation: ATA Scientific supplies KRÜSS instruments with modular accessories and high-throughput features such as Liquid Needle and Multi-Dosing Systems—ideal for streamlined, standardised testing in modern battery production.

Measuring surface tension doesn’t have to be complicated

Measuring surface tension is simpler than you might think, especially with the right tools. In battery research and manufacturing, mastering surface tension is not just a technical detail; it’s a performance driver. The way liquids wet, coat, and interact at interfaces directly shapes battery efficiency, safety, and lifespan.

With KRÜSS instruments from ATA Scientific, you can measure surface tension, contact angles, and surface free energy with precision and repeatability. Whether you need a portable device for quick QC checks or a fully automated analyser for advanced R&D, our modular systems are built for accuracy, consistency, and high-throughput workflows.

When you integrate these capabilities into your process, you’re not just collecting data—you’re accelerating innovation, optimising material compatibility, and boosting overall battery performance.

Bottom line: Accurate surface tension measurement is essential for building high-performance, reliable, and safe batteries.

Talk to ATA Scientific today for expert guidance and a hands-on demo—see how KRÜSS technology can optimise your battery R&D and production.

Sources:

Novel method to isolate Exosomes set to revolutionise translational opportunities.

July 3, 2025Newslettersatascientific

Extracellular vesicles (EVs) especially exosomes play a critical role in intercellular communication and are emerging as biomarkers for disease diagnostics and therapeutic delivery. Yet, the field continues to grapple with a familiar bottleneck—isolation and purification of EVs.

What’s the issue?

For years a multitude of scientists across the planet have tried to isolate exosomes. Many spend inordinate resources to fine tune existing paradigms such as Ultra-Centrifugation (UC) only to gain tiny steps on an existing technology that is limited. Plagued by low yield, long processing times, and high contamination from proteins, cellular debris, and unwanted nucleic acids, this is likely a root cause of the stagnation in progression of research.

Why EXODUS?

In late 2024, ATA Scientific was invited to assess a novel approach: the EXODUS automatic exosome isolation system. After visiting the facility behind the technology we were convinced (and gobsmacked) we had discovered a genuine leap forward for high efficiency exosome isolation – already capable of 10 L scale production.

Supported by multiple peer reviewed papers, this novel technology was published in the Nature Methods article (NATURE METHODS | VOL 18 | FEBRUARY 2021 212 | 212–218 | https://doi.org/10.1038/s41592-020-01034-x ).

So how does the EXODUS work?

The technology has been developed using a dual-membrane nanofiltration system that integrates periodic negative pressure oscillation (NPO) and double-coupled ultrasonic harmonic oscillations (HO). Whilst this sounds vaguely familiar- it is not a flux capacitor used for time travel like in the movie, Back to the Future! Essentially, it has filters that jiggle about releasing the exosomes to avoid the caking effect that blocks a filter and uses ultrasonic harmonic oscillations to keep the exosomes in suspension. The result? Dramatically improved purity and yield without damaging delicate vesicles.

Field-Proven Results Across Australia.

Curious whether it would hold up under local lab conditions, we brought EXODUS to several institutions including the John Curtin School of Medical Research in Canberra. The response? One user described the yield as “ridiculously high.” Similar outcomes followed in Brisbane, Melbourne, and Sydney, where researchers were impressed by how intuitive and fast the system is—yes, even Prof Barry Slim runs it himself!

At 50 – 100 nm these little guys are hard to see, unless you use a Malvern Panalytical NanoSight Pro Nanoparticle Tracking Analysis (NTA) system. The EXODUS results in yields beyond 90 %, purity around 98%, it is super-fast and gentle – avoiding damage to the EVs. EXODUS produces at lab scale to enormous volumes. It works so well we have prominent Professors visiting the factory to discuss scaling up opportunities for EXODUS in Australia.

Want to see it in action?

ATA Scientific is offering lab demonstrations of the EXODUS system—join the growing list of Australian labs eager to experience this game-changing technology first-hand.

Contact Pete Davis at ATA Scientific to book a trial or be notified when the system becomes available near you. Book online – click here

NEW LUNA-BX7 Automated BF Cell Counter

May 21, 2025New productsatascientific

Offering the same advanced software, machine-learning capabilities, and state-of-the-art precision and accuracy as the LUNA-FX7, the LUNA-BX7 offers researchers a brightfield-only option at a budget-friendly price point.

The small footprint makes it perfect for the benchtop and a great addition for busy labs with multiple users, a high volume of daily cell counts, or for labs needing bioprocessing features or GMP compliance. The high-resolution imaging and expanded concentration volume ensure accurate, reliable, and reproducible results.

The LUNA-BX7 offers 1-, 2-, 3-, and 8-channel slide configurations, similar to the LUNA-FX7.

The reusable slide provides an eco-friendly and budget-friendly option, while the disposable slides provide peace of mind for cell counts where cross-contamination is a factor. In addition, the user-friendly software makes it easy to switch between chambers. This means unused chambers in a multi-chamber slide can be used, eliminating waste.

High Performance, Integrated Connectivity, Quality Control, Bioprocessing & 21 CFR, Part 11 Features

The LUNA-BX7 to LUNA-FX7 upgrade pathway takes the LUNA-BX7 (brightfield optics only) and adds two-channel fluorescence optics, essentially converting the LUNA-BX7 into a LUNA-FX7 automated cell counter.

For more information visit LUNA-BX7 Automated BF Cell Counter – ATA Scientific

Advancements in Predicting Coatability: A Surface Science Approach for Optimised Adhesion

April 8, 2025Guides & Resources, Material Science - Guideatascientific

By Dr. Fiona Mary Antony, Adira Vaidyanathan (KRÜSS GmbH, Germany, kruss-scientific.com)

Coatings play a critical role in a wide range of industries, from automotive and aerospace to medical devices and consumer electronics. They serve as protective barriers against corrosion, wear, and environmental degradation while also enhancing aesthetics and functional properties such as hydrophobicity, conductivity, or anti-fouling behavior. However, the performance of a coating is only as good as its adhesion to the underlying substrate. Poor adhesion can lead to premature failure in the form of peeling, blistering, or delamination, ultimately compromising product reliability and longevity.

Surface analysis: the foundation of effective coating

Surface analysis plays a vital role in ensuring that coatings adhere properly by assessing the substrate’s physical and chemical properties. Traditional adhesion tests, such as ISO/JIS cross-hatch and ASTM tape tests, only evaluate final adhesion strength but fail to explain why adhesion is strong or weak.

To address this, modern surface free energy analysis provides predictive insights into coatability. Tools such as the KRÜSS Drop Shape Analyser measure key parameters like:

Work of adhesion (W_A): Determines the energy required to separate a liquid coating from a solid surface. A higher W_A indicates stronger adhesion.
Spreading coefficient (S): Predicts whether a liquid coating will spread or bead on a surface. A positive S value ensures good adhesion, while a negative value signals poor wetting.
Interfacial tension (Y_SL): Represents the energetic barrier between the coating and the substrate. Lower interfacial tension leads to better bonding and adhesion.

Enhancing coating adhesion with surface treatments

Low-energy surfaces, like untreated PP, exhibit poor adhesion due to their hydrophobic nature. To improve coatability, surface treatments such as:

plasma or corona treatment (modifies surface chemistry)
flame treatment (increases surface oxidation)
primer application (enhances bonding sites)

can be applied. Contact angle measurements before and after these treatments confirm increased surface free energy, leading to better adhesion.

Experimental results: KRÜSS ADVANCE adhesion analysis

The effectiveness of surface treatment in enhancing adhesion was evaluated by applying a water-based, one-component topcoat (1K) to polyamide (PA) substrates. This system is particularly relevant in printing and packaging applications, where polymer films require strong adhesion for high-quality prints, laminates, and coatings. Due to the inherently low surface free energy of polymeric materials, ensuring proper ink and coating adhesion remains a key challenge in these industries. To address this, Openair-Plasma^® treatment was employed at varying intensities to modify surface properties and improve wettability.

Surface characterisation and treatment impact

A crucial factor in achieving strong adhesion in printing and packaging films is surface free energy modification, as it directly influences wettability and coating spreadability. The untreated PA substrate exhibited a total surface free energy of 49.2 mN/m, with a low polar fraction (15.2%), making it less receptive to water-based coatings. As plasma intensity increased, the total surface free energy and polarity rose significantly, improving coating compatibility.

In contrast, the water-based 1K topcoat had a surface tension of 25.0 mN/m, primarily dominated by disperse interactions (19.0 mN/m) and a smaller polar contribution (6.0 mN/m). The increased polar fraction of plasma-treated PA substrates resulted in improved adhesion, which is essential in flexographic and digital printing processes where uniform ink spreading is required.

Adhesion performance and coating durability

For packaging films and printed labels, adhesion strength determines resistance to peeling, abrasion, and mechanical stress. To quantify adhesion, work of adhesion (W_A), interfacial tension (Y_SL), and spreading coefficient (S) between the 1K topcoat and the untreated/differently treated substrate were analyzed. Plasma treatment significantly influenced these adhesion parameters, demonstrating its impact on coating performance.

The untreated PA (PA1) showed the lowest work of adhesion (69.7 mN/m) and the highest interfacial tension, leading to weak ink and coating retention. For medium plasma treatment (PA5), adhesion improved, reducing coating detachment in high-speed printing applications. The highest plasma treatment (PA3) exhibited the strongest adhesion (81.0 mN/m), ensuring long-term durability of coatings on flexible packaging films. The results confirm that Openair-Plasma treatment plays a crucial role in enhancing adhesion by modifying the surface chemistry of polyamide substrates.

Additionally, the cross-cut adhesion test (ISO 2409) validated these findings, showing that higher plasma intensity leads to defect-free coatings suitable for demanding industrial applications. The untreated sample (PA1) showed significant delamination, while medium plasma-treated PA5 demonstrated reduced peeling.

Furthermore, we propose surface free energy and adhesion parameter measurements as a complementary method to traditional cross-cut tape tests. By leveraging KRÜSS ADVANCE software and contact angle analysis, these measurements provide a faster, quantitative, and more objective evaluation of substrate/coating adhesion, reducing dependency on time-consuming mechanical tests.

Industrial coatings: applications, types, and key performance parameters

Industry	Common coating types	Key performance parameters
Automotive	Epoxy primers, PU topcoats, electrocoats	* Corrosion resistance : protects metal components from rust and degradation. * Adhesion strength : ensures coatings remain intact * Flexibility : allows coatings to withstand mechanical stress without cracking
Aerospace	High-performance epoxy systems, PU systems	* Thermal stability: maintains integrity under extreme temperature fluctuations * Weight considerations: lightweight coatings are essential to not impede aircraft performance * UV radiation resistance: prevents degradation from prolonged sun exposure
Marine	Anti-fouling, anti-corrosive	* Saltwater resistance: protects against corrosive marine environments * Biofouling resistance: prevents accumulation of marine organisms on surfaces
Oil and gas	Epoxy and PU coatings	* Chemical resistance: withstands exposure to corrosive substances * Abrasion resistance: endures mechanical wear * Temperature resistance: maintains protective qualities under high-temperature conditions
Construction	Protective paints, sealants	* Weather resistance: shields structures from rain, UV rays, and temperature changes * Aesthetic quality: provides desired color and finish while maintaining performance

Modern adhesion analysis, using tools like the KRÜSS DSA series, transforms the way coatings are evaluated. By leveraging parameters like work of adhesion (W_A) and spreading coefficient (S), manufacturers can scientifically predict coating performance rather than relying on traditional pass/fail tests. This data-driven approach leads to:

Optimised coating formulations
Reduced material waste
Improved product reliability

Assessing coating stability through adhesion tests, environmental simulations, and chemical resistance evaluations further bolsters the dependability of coatings across various sectors. By integrating predictive adhesion analysis and surface free energy measurement, businesses can attain high-performance, sustainable coatings that endure even the most demanding environments.

DON’T WAIT – CONTACT US TODAY!

ATA Scientific Pty Ltd | Ph: +61 2 9541 3500 | enquiries@atascientific.com.au

References

Application Report 296: Predicting Coatability | KRÜSS Scientific
ASTM D3359-17, ISO 2409: Standard Test Methods for Measuring Adhesion by Tape Test.
Industrial Coating: Types, Techniques, and Applications | IQS Directory
Different Types of Industrial Coatings and their Applications | Thomas Industrial Coatings

FREE TRIAL OF MICROPORE’S PATHFINDER – A Better way to create nanoparticles

March 18, 2025Newslettersatascientific

Formulate your nanoparticles fast with high precision and easy scale-up. Apply for a free trial of this advanced crossflow mixing technology to accelerate liposome processing and nanoparticle formulation with highly controlled particle size.

APPLY HERE NOW

What is included

If your work requires you to formulate nanoparticles, particularly for drug delivery, you are encouraged to apply for a free trial of a Micropore AXF Pathfinder. You will need to provide a description of your research project including your current methods and formulation objectives. If we assess that the Pathfinder can provide significant advances for your project, then you could receive the following:

* Free use of a Micropore AXF Pathfinder unit

* Free use of supporting nano particle sizing analysers including fluorescence detection

* Training and support to optimise your formulation procedure

The Micropore Pathfinder is a compact Integrated benchtop unit for faster, cheaper, more efficient and scalable production of nanoparticles via advanced cross-flow mixing. Using a 316 stainless-steel precision engineered membrane, Pathfinder reduces the cost and accelerates the development of genomic medicines from lab bench to manufacturing scale. All this from a mixing device small enough to fit in the palm of your hand, easily disassembles, is simple to clean and requires no single-use consumables! This proven technology has multiple applications including pharmaceuticals/ medicines/ veterinary vaccines/ food/ cosmetics and chemicals.

How to apply

This free trial is open to researchers who work in organisations located in Australian or New Zealand. Priority will be given for projects that require scale up for future trial and manufacturing quantities. PhD and Masters students applications must include a letter of recommendation from their supervisor or manager. Please limit your application to 1 A4 page. Applications are now open.

The free trials will be offered for a period of 3 months starting from June 2025 until end of August 2025.

APPLY HERE NOW

Exosome Isolation: Purification and Characterisation Tools

January 16, 2025Biomolecular Science - Guide, Guides & Resourcesatascientific

WHAT ARE EXOSOMES?

Exosomes are a type of extracellular vesicle (EV) typically 30-150nm in diameter secreted by most human cells and enable cell-to-cell communication. Exosomes are found in abundance in body fluids including blood, urine, saliva, milk, semen, bile juice, ascites, cystic, bronchoalveolar and gastrointestinal lavage fluid and play a significant role in the transfer of biomolecules like proteins, lipids, RNA, DNA.

Exosomes have been found to be involved in multiple biological roles including immune responses, pregnancy, cardiovascular diseases, central nervous system-related diseases, and cancer progression. The molecular cargo they carry can reflect their cell origin so they are considered to be promising biomarkers for the diagnosis of cancer and other various diseases.

WHY ARE EXOSOMES IMPORTANT?

The study of exosomes is an active area of research which are being explored as a tool for disease diagnosis and treatment. Exosomes can be engineered to deliver diverse therapeutic payloads, including short interfering RNAs, antisense oligonucleotides, chemotherapeutic agents, and immune modulators, with the ability to direct their delivery to a desired target. Research into the characterisation of lipid nanoparticles highlights the importance of understanding and refining these delivery mechanisms for therapeutic applications. Ongoing research is enhancing our ability to harness their therapeutic and diagnostic potential. The need for more standardised purification and analytical procedures to study exosomes will likely reveal their functional heterogeneity.

Exosomes are being explored for their potential use as drug delivery vehicles of therapeutic RNA into specific parts of the body such as the brain in the treatment of neurological disorders including Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease. Research into the role of exosomes in therapeutic applications has highlighted their potential for safe and efficient delivery systems. While there are many benefits in exploring the use of exosomes for the safe and efficient delivery of their cargo, major challenges related to their isolation are highlighting development opportunities.

Therapeutic Applications of Exosomes and Associated Challenges

Therapeutic Application	Target Diseases	Key Challenges
Drug Delivery Vehicles	Neurological Disorders: Alzheimer’s, Parkinson’s, Huntington’s	Efficient Targeting and Delivery
RNA Therapeutics	Cancer Treatment	Purity and Yield of Isolated Exosomes
Immune Modulation	Autoimmune Diseases	Heterogeneity in Size and Composition
Biomarker Discovery	Cancer, Cardiovascular Diseases	Lack of Standardised Isolation Techniques

WHAT ARE THE CHALLENGES IN ISOLATION AND CHARACTERISATION?

Reliable isolation and characterisation of extracellular vesicles (EVs) are critical for advancing drug discovery and play a key role in disease detection and treatment. The ability to quickly identify elevated exosome concentrations, as detailed in the comparative analysis of exosome isolation methods, can signal the onset or progression of disease, offering valuable diagnostic insights. Additionally, leveraging the unique properties of EVs as drug-delivery vehicles presents an exciting and innovative approach to combating various diseases.

However, EVs extracted from bodily fluids in response to specific conditions are highly heterogeneous, varying in size, composition, and function. This complexity makes the characterisation of these vesicles an especially challenging yet essential task for researchers.

The need for precise and accurate characterisation of exosomes will continue to grow as our knowledge of the heterogeneity of EVs, their cargo, and their functions evolves. Exosome identification and isolation have the potential to substantially improve our understanding of the basic biology of exosomes and their use in applied science and technology. Such knowledge will inform the therapeutic potential of exosomes for various diseases, including cancer and neurodegenerative diseases.

With increasing potential for their clinical utilisation, it has become imperative to optimise exosome isolation methods for maximum yield, purity and assay reproducibility. Besides the traditional ultracentrifugation method, there are currently several commercial exosome isolation kits developed based on different principles such as charge neutralisation-based precipitation, gel-filtration, affinity purification using magnetic beads, etc. However, these methods can generate significant challenges in exosome isolation, particularly with yield, purity and quality.

Challenges of Current Exosome Isolation Methods:

Different exosome isolation methods can yield different amounts of exosomes
The size distribution of exosomes can significantly vary among preparations from different isolation methods.
Exosomes isolated from different isolation methods can show differences in their zeta potential
The quality of exosomes can differ from different isolation methods affecting functional applications
High cost of disposable modules/consumables, high shear stress involved and inflexible sample volumes

There is therefore a need for a new technology to improve exosome purification in terms of efficiency, purity, yield, speed and robustness. A standardised approach to exosome isolation and characterisation will enable research dependability and translational success. For more information, read this comprehensive analysis of exosome isolation methods.

Clog-Free Ultra Fast Exosome Purification With Exodus

Traditional methods for isolating exosomes, while effective for size-based separation, often suffer from clogged membrane pores, which disrupt continuous processing. These limitations are addressed in recent advances in exosome isolation technologies. To solve this issue, the EXODUS system uses a unique design that combines advanced oscillation technology with a dual-membrane filter.

Comparison of Traditional Exosome Isolation Methods vs. EXODUS System

Feature	Traditional Methods	EXODUS System
Purity	Moderate; impurities often remain	High; impurities effectively filtered
Yield	Variable and inconsistent	High and reproducible
Processing Speed	Time-consuming (hours to days)	Ultra-fast (minutes to hours)
Risk of Clogging	High due to membrane pore blockages	Low; clog-free design
Scalability	Limited to small volumes	Scalable for high-throughput workflows
Cost of Operation	High; frequent consumable replacements	Cost-efficient; durable components
Ease of Use	Manual steps prone to errors	Automated and user-friendly
Compatibility	Limited sample types	Broad compatibility across samples

HERE’S HOW IT WORKS

Smart Filtration: The system uses periodic negative and air pressure switching to create oscillations on a nanoporous membrane. This allows small impurities, like proteins and nucleic acids, to pass through, while exosomes are retained in a central chamber.
Anti-Clogging Technology: Double harmonic oscillators generate waves and fluid movement that keep particles suspended in liquid. This prevents clogging and particle aggregation, ensuring smooth and efficient operation.

The result is a fast, reliable, and clog-free way to purify exosomes, ideal for research and clinical applications. Recent advancements in automatic, label-free exosome isolation have demonstrated significant improvements in efficiency and yield, offering a breakthrough for researchers.

The EXODUS Exosome Isolation System is an automated platform designed to streamline the purification and enrichment of exosomes. This system leverages advanced nanofiltration and oscillation technologies to provide a fast, efficient, and highly reliable solution for exosome research.

Key Features of the Exodus System:

High Purity and Yield:

Ensures consistent recovery of high-quality exosomes suitable for downstream applications, such as biomarker discovery, therapeutic development, and basic research.

Dual-Membrane Nanofiltration:

Incorporates a nanoporous membrane for precise, label-free separation.
Effectively captures exosomes while filtering out impurities like free nucleic acids and proteins.

Clog-Free Operation:

Designed to overcome common issues with membrane blockages found in traditional methods.
Supports continuous and ultra-fast isolation, ideal for high-throughput workflows.

Automated and User-Friendly:

Intuitive interfaces and automated protocols make it accessible for researchers at any level of expertise.

WHY CHOOSE THE EXODUS SYSTEM?

The EXODUS system addresses key challenges in exosome isolation by providing a reliable, scalable, and reproducible solution. It is ideal for a wide range of applications, including disease biomarker identification, Therapeutic exosome production and Fundamental studies on exosome biology.

With its advanced, compact design, the EXODUS system empowers researchers to focus on advancing their exosome studies, reducing manual intervention, and improving data consistency.

Once exosomes have been isolated and purified, they need to be characterised.

Exosome Characterisation Techniques

WHAT IS NTA?

Nanoparticle Tracking Analysis (NTA) is the method of choice and a standard tool that has assisted exosome researchers for over a decade, providing detailed insights into NTA for exosome characterisation. NTA visualises and measures the light scattering from individual EVs moving under Brownian motion offering high-resolution size and concentration characterisation of EVs in their natural environment.

How is NTA Useful?

Understand the role exosomes play in disease, and how they can be utilised in diagnostic or therapeutic applications, with size and concentration data.
Optimise isolation and purification methods with detailed insight into exosome heterogeneity. Changes in size distribution can often indicate disease stage, which is important in diagnosis.
Easily assess batches to confirm production and sample consistency of EV samples
Detect subpopulations of intact vesicles, common and specific biomarkers, and cargo using fluorescence capabilities.

The newest instrument, NanoSight Pro has evolved to include intelligent NS XPLORER software and enhanced sensitivity. Powered by machine learning, the NanoSight Pro provides guided workflows, automated processing, and automated particle identification to provide easy, quick, and accurate analysis. High sensitivity detection enables very detailed information about samples in both the light scatter and fluorescence modes. For further details, explore the benefits of using nanoparticle tracking analysis, a key tool for exosome characterisation. This allows NanoSight Pro to detect exosomes as small as 30nm in just minutes. Furthermore, samples can be recovered in their native form after the measurement. NTA can detect the presence of antigens on EVs by applying fluorescently labelled antibodies. By enabling specific detection of these biomarkers and cargo, users can better understand the behaviour of extracellular vesicles and decode their messages.

WHAT IS DLS?

Dynamic Light Scattering (DLS), also known as Photon correlation spectroscopy, is a non-invasive, well-established technique for measuring the size and size distribution of molecules and particles typically in the submicron region, and with the latest Malvern Panalytical Zetasizer technology, lower than 1nm. DLS is a complementary technique to NTA and can be used for measuring the size of exosomes. The method employs a monochromatic laser that passes through a liquid suspension of particles. Time-dependent fluctuations in the intensity of scattered light caused by Brownian motion of particles are observed and their velocity or translational diffusion coefficient is measured which can be converted into a hydrodynamic diameter.

While both DLS and NTA follow the Brownian motion of dispersed light from the target particles, they operate in different ways. NTA measures individual particle diffusion. DLS measures changes in the intensity of scattered light on a bulk sample. Both methods offer several different benefits and therefore by combining the two techniques users can take advantage of the complementary information they provide.

NTA can often provide higher resolution size measurements, but DLS can offer a faster assessment of the mean size and polydispersity. For perfectly monodisperse samples both DLS and NTA should give the same result.
DLS is most suitable for particle sizes larger than ~1 micron, for quality control of nanoparticle production and for early detection of aggregates.
NTA is most suited for polydisperse distributions where users require a higher resolution of peaks and want to measure the concentration of nanoparticles.
For NTA, users can selectively look at only a fluorescently tagged part of the distribution, while in DLS fluorescence can affect the measurements and require a filter (e.g. quantum dots).
NTA can detect samples 10-1000 times more dilute than DLS.
DLS can handle a wider concentration range without dilution.

The Zetasizer Advance range of instruments are the most widely used dynamic light scattering (DLS) instruments measuring particle and molecular size, particle charge and particle concentration from less than a nanometer to several microns. Combining novel measurement capabilities together with an artificial intelligence (AI) led approach to data quality assessment, the new Zetasizer systems help gain more insight and further confidence to reliably characterise the size and surface charge of colloids, biomolecular nanoparticles; screen protein formulations for colloidal stability and the presence of aggregates; and, assess the shelf-life and stability of complex formulations.

Building on the legacy of the industry-leading Zetasizer Nano series, the three core models, Zetasizer Lab, Zetasizer Pro and Zetasizer Ultra, can be tailored and quickly upgraded to suit specific application needs.

Each benefit from the latest advances includes:

Adaptive Correlation, a statistically driven approach to produce the best correlation data, without the need for sample filtering to deliver reliable, faster size measurements and added confidence in results.
Multi-Angle Dynamic Light Scattering (MADLS) for calibration-free measurement of particle concentration.
Novel constant current zeta mode – allows for high ionic strength measurements previously not achievable. Improved zeta sensitivity requires much lower sample concentrations for a zeta measurement, saving precious material.
Size Quality Guidance – AI-guided data quality advice allows even a novice without any prior light-scattering knowledge to make sense of sizing data.
The fluorescence filter wheel allows for extended applications with fluorescent samples, like quantum dots. Polarisation filters, both vertical and horizontal polarisation components can be detected, potentially gaining insights into particle rotational diffusion.
Novel 3 μL low volume size cell, lowers sample volume and extends concentration range.
Works with OmniTrust: Malvern Panalytical’s compliance solution for the regulated environment

In addition to the above, more than 100k publications are using the Zetasizer.

Would you like to learn more about Exosome isolation characterisation tools? Contact our team for expert consultation.

Contact us for a personal demonstration within your lab using the Malvern Zetasizer Ultra, Malvern NanoSight and EXODUS auto exosome isolation system today! Contact us.

Advancing Tissue Engineering using Phenom Desktop SEM

January 9, 2025Guides & Resources, SEM & Imaging - Guideatascientific

What is Tissue Engineering?

Tissue engineering is an innovative and rapidly evolving field in medical science focused on creating biological substitutes to repair, replace, or enhance the function of damaged tissues and organs. It encompasses regenerative medicine, stem cell therapies, decellularised or engineered organs, and electrospun scaffolds. Applications of tissue engineering include treating burn injuries, diabetic wounds, and diseases that compromise tissue functionality.

The ultimate goal is to develop functional tissues that can mimic or even improve the normal operation of the damaged area. For example, stem cells extracted from a patient’s bone marrow can be grown and differentiated into cartilage cells (chondrocytes). These are then seeded onto an optimised scaffold matrix, designed to mimic the original tissue, and transplanted into the patient.

To achieve success, scientists must understand the tissue’s structure and properties, including its interaction with cellular adhesion, porosity, and biocompatibility.

By analysing scaffold structures with tools like the Phenom SEM, scientists are advancing the possibilities for tissue regeneration in humans. Detailed imaging helps refine scaffold designs and monitor cellular interactions, paving the way for more effective regenerative therapies.

This understanding ensures that engineered tissues can withstand normal functionality while promoting cellular interactions essential for repair and regeneration.

HOW CAN TISSUE ENGINEERING ASSIST WITH WOUND HEALING?

Wound healing is the process of replacement of destroyed or damaged tissue. While closing a wound might seem like the primary goal, it’s equally important to focus on the repair process occurring underneath.

There are different types of wound healing. Wound regeneration is the process of healing tissue fully restoring its normal function. Wound repair is the process of healing tissue without restoring it to its normal function, such as a scar where hair no longer grows.

Within wound healing, there are three different stages including;

Inflammation: Prepares the wound for healing.
Proliferation: Generates new tissue.
Remodelling: Strengthens the new tissue.

Delays in any stage can lead to infections, which tissue-engineered scaffolds can prevent. These scaffolds promote regenerative healing by enhancing wound closure, providing nutrients, and creating an optimal environment for cellular interactions.

Optimising a tissue engineering scaffold is crucial for promoting cellular adhesion, growth, and regeneration. Phenom SEM’s advanced imaging capabilities provide detailed insights into scaffold porosity, fiber thickness, and structural integrity, ensuring these synthetic matrices mimic natural extracellular environments effectively.

Properties like porosity, thickness, and mechanical strength significantly influence the success of wound healing.

HOW ARE TISSUES EXAMINED DURING WOUND HEALING?

Microscopy is an essential tool in wound healing research. Techniques like light, fluorescent, and confocal microscopy allow scientists to examine tissue samples, often stained with hematoxylin and eosin (H&E), to assess the cellular structure and observe changes in the skin’s layers.

Comparison of Microscopy Techniques in Wound Healing

Microscopy Technique	Resolution	Sample Preparation	Applications in Wound Healing	Key Advantages
Light Microscopy	Micrometer scale	Simple staining (e.g., H&E)	Examines overall tissue structure and cellular arrangement	Cost-effective and easy to use
Fluorescent Microscopy	Sub-micrometer	Fluorescent dyes or markers	Highlights specific cell types or proteins in tissue samples	High specificity and contrast
Confocal Microscopy	Nanometer scale	Laser scanning with dyes	Provides 3D imaging and layer-by-layer analysis of wound tissues	High resolution and depth information

Evaluating the Applications of Light, Fluorescent, and Confocal Microscopy

WHY USE SEM IMAGING FOR TISSUE ENGINEERING?

Scanning Electron Microscopy (SEM) provides high-resolution imaging at the nanometer scale, making it invaluable for studying tissue structures and morphologies, as discussed in biomedical research applications. Compared to optical microscopy, SEM offers finer details, a greater depth of field, and elemental analysis capabilities using an Energy Dispersive Spectroscopy (EDS) detector.

The Phenom desktop SEM series is particularly advantageous for tissue engineering offering high-resolution imaging of the tissues or synthetic tissue structures, the ability to observe the presence of cells and to analyse the surface topography.

3D bioprinting combined with SEM imaging enables tissue engineers to examine microstructures and ensure that bioprinted tissues meet necessary specifications for cellular proliferation and mechanical strength.

From the entry-level SEM to a system with access to a larger sample compartment or field emission (FEG) source for ultra-high resolution, low kV imaging with STEM detector, all Phenom SEMs offer high speed, and ease of use with a small footprint. They all come standard with x y stage movements, a digital optical microscope that stays with you throughout the entire time of imaging to help find different locations on your sample, a charge reduction mode that allows users to image samples without having to coat them with a gold or platinum layer, and as well as the ability to add on Python scripting. Different software options provide the ability to measure different parameters that can help promote wound healing, such as porosity measurements, fiber diameter measurements, and tensile strength measurements.

APPLICATIONS OF PHENOM SEM IN TISSUE ENGINEERING

1. Skin Grafts or Bioengineered Skin Substitutes

Skin grafts or bioengineered skin substitutes are the standard of care for treating third-degree burns, where skin damage extends to the hypodermis and nerve endings are destroyed. Skin grafts can help prevent infections and can be autologous – where is skin taken from the same person and then transplanted to that damaged area, or allogeneic, when grafts from another person and transplanted to another patient. Before transplantation, tissues go through decellularisation – a method that removes the cells – to prevent patients from having an immune response that can lead to rejection of the tissue. Decellularisation usually leads to an extensive amount of tissue damage which compromises the success of a skin graft.

The Phenom SEM can evaluate the success of decellularisation processes by assessing tissue porosity and cellular removal. P henom’s integrated PoroMetric software calculates pore characteristics to analyse tissue damage caused by different decellularisation treatments. Research by Dr. Dominic Dominguez, Application Scientist Nanoscience Instruments, found normal skin had an average porosity of 43.41% compared to skin after Tonicity treatment having an average porosity of 46.2% and Triton X-100 having an average porosity of 62.88%. The results demonstrated that Tonicity treatment had similar per cent porosity compared to the original skin samples and thus preserved tissue structure better than Triton X-100.

Porometric software also indicated that Tonicity treatment removed cells from the tissue, whereas Triton X-100 did not completely remove all the cells and caused more destruction to the tissue compared to using Tonicity. Overall, the Phenom SEM was able to help determine that the Triton X-100 treatment was not successful at removing cells and it actually caused more destruction to the tissue structure compared to the Tonicity treatment.

2. Electrospun Fibers Used as Synthetic Tissue Scaffolds

Electrospun fibers are used as synthetic tissues to mimic the extracellular matrix for cellular migration and proliferation. The needle-based technique applies a voltage to a polymer solution in a syringe which creates fibers that are spun onto a collector to create a scaffold with a specific structure, porosity, and thickness. Changing the reagents helps determine different biomimetic cues in the body. The presence of growth factors can be altered to increase the proliferation of cells, induce cellular migration, or even enhance wound healing.

Phenom SEM imaging can be used to observe the process of electrospinning. Researchers studying lipid-infused electrospun scaffolds used the Phenom to confirm biocompatibility and measure fiber diameters. The Phenom FiberMetric software enabled automatic fiber diameter measurements, revealing that increased lipid concentration decreased fiber size without hindering cellular growth. The control had an average fiber size of 1.5 microns compared to the 10% treatment having an average fiber size of 0.93 microns. The FiberMetrics software can capture multiple measurements within seconds and provides reporting measurements to understand the mechanical properties of the tissue or the tissue’s replacement.

3. Tensile Strength Testing

During the scar formation after a wound is healed, did you know that only 70% of the normal tensile strength is recovered compared to the original skin? Being able to mimic or improve the original tissue’s mechanics is the goal of wound healing. Using an electrospun scaffold can aid with strengthening the mechanical properties, and there are various tools used to measure the mechanical properties as well, such as a mechanical tester or a rheometer.

The Phenom XL with the tensile stage allows users to measure the tensile or compressive strength of a material, to view it live under SEM imaging and to record the force and distance in order to calculate the stress and strain of a material. Another useful feature in the Phenom XL is users can navigate to find the same area of interest previously visited so comparisons can easily be made quickly and easily and it’s not like finding a needle in a haystack.

Impact of Lipid Concentration on Fiber Thickness

WHY CHOOSE PHENOM SEM FOR TISSUE ENGINEERING?

Key features include:

Charge reduction mode for imaging nonconductive samples without coating.
Software tools like PoroMetric and FiberMetric for detailed pore and fiber analyses.
A tensile stage for live mechanical testing.
Versatile detector modes (BSD and SED) for capturing elemental and topographical details.

Phenom SEM combines high resolution at high magnification imaging with an intuitive, easy-to-use interface that allows even novices to quickly obtain their first high-quality results. It offers multiple detector modes including Backscatter detector (BSD) and Secondary Electron Detector (SED) modes as well as elemental identification using the integrated Energy Dispersive Spectrometer (EDS or X-ray) detector. Images can be captured with either the BSD, SED or have both detectors on simultaneously. This percentage can be adjusted to capture the elemental contrast from the backscatter detector and topography from the secondary electron detector.

Phenom’s charge reduction mode and the ability for low kV imaging accommodates insulating and beam-sensitive samples with a resolution of 2.0 nm that reveals the finest details. When imaging non-conductive samples, many users will experience charging on samples, making it difficult to collect an image. One way to fix this problem is by coating samples with gold or platinum. The Phenom charge reduction sample holder and software also can adjust the vacuum settings (high to low) to capture images of nonconductive samples without coating and still run elemental analysis using the EDS detector.

The integrated PoroMetric software allows the user to gather data on the distribution of pores and pore parameters like pore size and aspect ratio. Similarly, Phenom FiberMetric Software enables measurement of micro- and nanofibers. Tensile Sample Holder for Phenom XL allows for tensile testing. By measuring the force required to elongate a specimen to the breaking point, material properties can be determined which will allow designers and quality managers to predict how materials and products will behave in their intended applications.

With the Phenom SEM, tissue engineers can analyse scaffold structures, optimise designs, and ensure successful tissue regeneration, paving the way for new advances in wound healing and tissue engineering.

Would you like to learn more about our Advancing Tissue Engineering analysis and solutions? Contact our team for expert consultation.

To learn more about these innovations and discover even more features of the Phenom SEM or Morphologi 4ID and Mastersizer 3000+, Contact us.

NEW AccuPore – the Most Advanced Capillary Flow Porometer

December 18, 2024New productsatascientific

Introducing the new Micromeritics AccuPore Capillary Flow Porometer (CFP) – a fast, and reliable method to determine the size distribution (13nm to 500µm) of through-pores, i.e pores that span from one side of a surface of a material to the other. CFP is a non-destructive technique and an important measurement in the development or production of the sheet-goods used for membranes, separators, filtration media, technical fabrics and more.

Unlike traditional CFP systems, the AccuPore uses a compressor for low-pressure operations (bubble point measurement and large pores) and switches to high-pressure bottled gas for analysis of small pores, reducing the need for expensive high-pressure gas.

The flexible design of the AccuPore CFP makes it simple to move between a variety of sample diameters all within the same sample chamber. A selection of sample supports provide reliable measurements to the highest pressures, even for thin or weak membranes while also reducing gas consumption by up to 95%.

Gas-liquid CFP is a direct complement to mercury intrusion porosimetry (MIP), providing a rich description of pore architecture. The AccuPore is particularly valuable for users requiring high precision in characterising filtration efficiency or material permeability especially for optimising the design and performance of battery separators and fuel cell membranes.