Malvern Zetasizer Ultra

The Zetasizer Ultra, the most advanced light scattering system, delivers enhanced resolution, speed and ease-of-use for the measurement of particle and molecular size, particle charge and particle concentration.

Malvern Zetasizer Ultra

The Zetasizer Ultra, the most advanced light scattering system, delivers enhanced resolution, speed and ease-of-use for the measurement of particle and molecular size, particle charge and particle concentration.

Manufacturer Malvern Panalytical
Product Series Malvern Zetasizer
Measurement principle Dynamic Light Scattering, Multi-Angle Dynamic Light Scattering (MADLS)
Application Molecular Weight & Size, Nano Particle Size, Protein Crystallisation, Zeta Potential
Size range0.3 nm - 10 μm (diameter)
Measurement angle173°, 13°, 90°
Sample volume3μL
Particle concentration range1 x 10⁸ - 1 x 10¹² particles/mL
Sample concentration range0.1 mg/mL to 40% w/v

Product Overview

The Malvern Zetasizer Ultra is the most advanced system for the measurement of particle and molecular size, particle charge and particle concentration. 

Zetasizer Ultra is the highest performance system in the new Zetasizer Advance range which comprises of three core models: Zetasizer Lab, Zetasizer Pro, and Zetasizer Ultra. Each model is available in two variants: a Blue Label version for routine sample investigation and a Red Label version for use with more challenging samples. 

Built on the market-leading Zetasizer Nano range, the new Zetasizer Ultra delivers enhanced speed and ease of use, accelerating sample throughput and freeing up operator time for other tasks.

Alongside the patented Non-Invasive Back-Scatter (NIBS) technology, the Zetasizer Ultra offers Multi-Angle Dynamic Light Scattering (MADLS®) which automates multiple-angle size measurements, providing higher resolution and more complete particle size distributions. MADLS also enables calibration-free particle concentration analysis for a wide range of materials, resolving the individual concentrations of different size populations to provide even greater insight into your samples.

The new disposable capillary sizing cell provides the ultimate in non-destructive, low volume (3μl) analysis, extending the upper range to 10μm and delivering high-quality data while reducing cost.

The Zetasizer Ultra is controlled by user-friendly ZS Xplorer software, introducing new sample-centric workflows, which make method design and data analysis more straightforward.  A new algorithm called Adaptive Correlation applies intelligent logic to separate data associated with the presence of dust or aggregates, filtering these from the results to give a more representative overall picture of the sample. This is supported by integrated, deep-learning empowered data quality guidance, offering the user instant feedback on their results and providing actionable advice.

  • Demonstration video
  • Benefits
  • Applications
  • Accessories

Demonstration video


  • Multi-Angle Dynamic Light Scattering (MADLS) for high resolution angle-independent size measurements offers greater insight into the size distribution of your sample.
  • Disposable capillary sizing cell provides the ultimate in non-destructive, low volume (down to 3 μL) analysis, with an upper size range that extends to 10 μm.
  • Simple, calibration-free measurement of particle concentration in homogeneous sample types, covering a wide range of materials.
  • Electrophoretic Light Scattering (ELS) measures the zeta potential of particles and molecules, indicating sample stability and/or propensity to aggregate.
  • Sample-centric ZS Xplorer software enables flexible, guided use, and the capability to build complex methods with ease.
  • Optical filter wheel offers a fluorescence filter and both vertical and horizontal polarisers for analytical flexibility.
  • NIBS (Non-Invasive Back-Scatter) technology maximises the dynamic range, providing the highest sensitivity for even the most concentrated samples
  • The deep-learning empowered Data Quality System assists users in understanding which of their size data might be poor, and why. This intelligent neural network system also suggests how to improve results.
  • Adaptive Correlation produces reliable and repeatable data over twice as quickly, providing a truly representative view of the sample.
  • M3-PALS with Constant Current Mode measures electrophoretic mobility and zeta potential in high conductivity media.


  • Bioscience and biopharmaceuticals: simple purity and stability screening can assist with formulation development. Time, temperature, pH and shear can all impact biological molecules and cause aggregation, which is detected by Zetasizer instruments.
  • Pharmaceuticals and drug delivery: effective therapeutics must be delivered safely, with dispersion quality and stability being critical quality attributes.  Zetasizer systems can help speed up formulation development and final product development by providing insight earlier in the development pipeline.
  • Paints, inks, and coatings: the stability of formulated nanoparticle suspensions is important, and both size and zeta potential help optimise product performance. Non-invasive back-scatter analysis can be used over a wide concentration range, with no/minimal dilution.
  • Advanced Nanomaterials: Zetasizer instruments’ high sensitivity and low sample volume requirement can help guide in the early research and development phase of advanced materials design for materials like graphene, catalysts, and nanotubes.
  • Food and drink: appearance, stability and flavour emulsions are all influenced by some of the nanoscale properties light scattering can measure –  not only particle size but also particle charge can influence the final consumable product.
  • Consumer products ranging from detergents to cosmetics. Understanding of colloidal stability and control or adjustment of performance parameters helps guide product development.
  • Academia: As an essential analytical instrument in many educational settings and academic research laboratories, tens of thousands of scientific publications attest to the widest range of suitable applications – and the particular ease-of-use and built-in reliability of Zetasizer systems have helped make them the favoured ‘go-to’ tools for rapid ensemble average size as well as zeta potential determination.


MPT-3 Auto titrator

Designed to automate the measurement of size and zeta potential as a function of pH.

Zetasizer ultra titrator

SV-10 Viscometer
Measures viscosity for the conversion of diffusion speed to size, and electrophoretic mobility to zeta potential. Useful for complex dispersants for which there are no available standard literature values for viscosity.

SV 10 viscometer

Disposable and reusable cells

A range of cells are available to optimise the measurement in terms of sample volume and concentration, including the new low volume disposable sizing cell kit, which offers the dual benefits of size measurements in as little as 3μL, and extension to the upper size range of DLS measurements.

*  New disposable folded capillary cell 

This new capillary enables contamination-free, high accuracy size, zeta potential and protein mobility measurements in as little as 20 μL of sample. The new capillary shape provides improved repeatability along with enhanced thermal performance.

Disposable folded capillary cell








*  Low volume disposable sizing cell 

A very low volume (minimum 3 μL) disposable sizing cuvette which extends the size measurement range for the Zetasizer without density-matching of the dispersant.

Low volume disposable sizing cell

*   Universal ‘dip’ cell kit
A reusable solvent resistant cell for the measurement of zeta potential in aqueous and non-aqueous dispersants using polystyrene or glass cuvettes.

Universal ‘dip’ cell kit

*  High concentration zeta potential cell kit
This high concentration cell enables measurement of the zeta potential of samples with little or no dilution required.

High concentration zeta potential cell kit










*  12 mm square glass cuvette

Compatible with both aqueous and non-aqueous solvents and dispersants, and is used for size measurements.

12 mm square glass cuvette

* Low-volume quartz cuvette

Holds between 12 μL and 45 μL of sample and is used for size measurements. It is compatible with both aqueous and non-aqueous solvents.

Low-volume quartz cuvette

* 12 mm glass cell

Used for size and zeta potential measurements using the ‘dip’ cell, compatible with both aqueous and non-aqueous solvents and dispersants.

12 mm glass cell










* 12 mm square polystyrene cuvette

For size measurements, and also for zeta potential measurements when used with the ‘dip’ cell. This cuvette is typically used for samples where cross-contamination might be an issue.

12 mm square polystyrene cuvette

* Disposable micro-cuvette

Holds a maximum sample volume of 40 μL. Compatible with both aqueous and non-aqueous solvents and dispersants for size measurements.

Disposable micro-cuvette

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