Product Overview

The WAVEsystem provides rapid, label-free and high-sensitivity analysis to study real-time biological interactions providing deeper insight into the affinity and kinetics of the interaction as well as binding specificity.

Engineered around the patented Grating-Coupled Interferometry (GCI) technology, a range of analytes can be investigated in just one system to manage a broader range of samples than traditional SPR equipment.  This extremely versatile technology can screen crude and complex samples involving fragment, small molecules, peptides, membrane proteins, biologics and other molecules even in crude reaction mixtures and biofluids like undiluted serum and plasma.

Large molecules with high affinity and slow dissociation can be measured simply (even native proteins in complex matrices) without purification. This is made possible by WAVEchip, a microfluidics pathway that is fully contained in single, disposable 2- or 4 channel cartridge complemented by integral no-clog technology. 

With ultra-fast transition times (up to 150ms), reliable determination of off-rates of 10s-1 can be calculated for the kinetic study of small and weak binding fragments. This is aided by monitoring through the waveguide so that an increased number of binding interactions can contribute to the overall signal.

The waveRAPID (Repeated Analyte Pulses of increasing duration) method can also be used to increase throughput compared to multi-cycle kinetics, particularly in screening applications, by generating a pulsating concentration profile.

Easy-to-use software, WAVEcontrol, makes data interpretation and evaluation straight forward. The kinetic series can be evaluated in just one click, as the software automatically adjusts the data and initiates the evaluation process. Smart wizards extend the automated capabilities of the system and include: Ligand screening – a faster, flexible way to screen and characterise antibodies and Calibration-free concentration analysis (CFCA) – a reliable, quick and easy calibration-free approach to quantify active protein concentration.