Malvern MicroCal PEAQ-DSC

MicroCal PEAQ-DSC is a highly sensitive, easy-to-use Differential Scanning Calorimeter (DSC) that provides insights into biomolecular stability without labelling or use of artificial probes.

Malvern MicroCal PEAQ-DSC

MicroCal PEAQ-DSC is a highly sensitive, easy-to-use Differential Scanning Calorimeter (DSC) that provides insights into biomolecular stability without labelling or use of artificial probes.

Manufacturer Malvern Panalytical
Product SeriesMalvern MicroCal DSC
Measurement principleDifferential Scanning Calorimetry (DSC)
ApplicationBiomolecular Interactions
Sample typeProteins, biomolecules
Sample throughputup to 6 samples/8hr
Working cell volume130 µL
Typical sample concentration0.01 to 10mg/mL
Maximum scan rate240ºC/h
Temperature range-10 ºC to 130 ºC2ºC to 130 ºC
Response time5s

Product Overview

MicroCal PEAQ-DSC is a highly sensitive Differential Scanning Calorimeter used to accurately determine the transition midpoint (Tm) and provide insights into biomolecular stability and the mechanisms of folding and unfolding. It measures very tight binding constants, up to 1020M-1 and allows for unattended operation after sample loading. This complete system requires no additional accessories, reagents or consumables.

Differential Scanning Calorimetry generates a thermodynamic profile to provide insight into the factors that affect conformation and stability. During a measurement, the reference and sample cells are heated at a constant scan rate which causes the molecule to undergo a conformational change such as unfolding. This results in the absorption of heat with the midpoint (Tm) indicating stability and the area under the curve (ΔH) giving the enthalpy of the process.

Typical applications include determining protein stability and the thermodynamics of unfolding, antibody domain structure determination and the characterisation of membranes, lipids and detergent micellar systems

  • Benefits
  • Applications

Benefits

Label Free
Molecules can be studied in their native state without labelling. It requires minimal assay development and is ideally suited for solutions that interfere with optical measurements including turbid, coloured or particulate samples.

Excellent chemical resistance
Nonreactive Tantalum cells ensure excellent chemical resistance and inertness when working with proteins and other biomolecules.

Includes ThermoVac sample preparation and cleaning device
Complete system requires no additional accessories, reagents or consumables. Once the samples are loaded it operates unattended, freeing the user for other tasks.

Intuitive software
Designed to streamline workflow by providing simplified experimental setup. A range of thermodynamic fitting models support a variety of applications and further aid data analysis and interpretation.

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Applications

  • Characterising and selecting the most stable protein or biotherapeutic candidate in drug discovery
  • Eliminate protein or biotherapeutic candidates likely to have long-term stability issues
  • Optimising expression, purification and manufacturing conditions in drug discoveryRapidly and easily determining the conditions for liquid formulation in drug discovery
  • Using DSC to study antibody Fab region stability for improved biotherapeutic development
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