Introducing Apollo, the automated, high sensitivity, protein structural characterisation tool
Apollo provides ultra-sensitive, ultra-precise measurements of the structure of biomolecules through a novel technology called Microfluidic Modulation Spectroscopy (MMS), now even more rapidly, with less sample volume, and with improved software and analytics features.
MMS overcomes many of the limitations of existing technologies in a typical biophysical characterisation toolkit with ultra-sensitive and highly reproducible structural measurements of proteins and other biomolecules. Users are able to compare higher-order structure and similarity profiles for confidence in structural similarity and activity to inform discovery, screening, formulation, and quality control in biopharmaceutical drug development. It can be used for a wide range of biomolecules from mAb-based biotherapeutics to robust measurements of ADCs, AAVs, and mRNA.
Key features and benefits of Apollo include:
- Accurate and reproducible measurements with broad concentration range from 0.1 mg/ml to >200 mg/ml allows measurements in native conditions
- 20x faster and 30x more sensitive to changes in structure than CD or FTIR
- Real-time buffer subtraction minimises background noise and interference from excipients
Dramatically reduced sample volume requirements