Malvern Morphologi 4

Malvern Morphologi 4 rapidly measures particle size, shape, transparency, count and location of dry powders, fibres and wet suspensions using automated static imaging analysis.

Malvern Morphologi 4

Malvern Morphologi 4 rapidly measures particle size, shape, transparency, count and location of dry powders, fibres and wet suspensions using automated static imaging analysis.

Manufacturer Malvern Panalytical
Product SeriesMalvern Morphologi
Measurement principleMicroscopy - Image Analysis
ApplicationParticle Shape, Count & Chemical ID
Sample typePowders, suspensions, fibres
Particle size range0.5µm to >1300µm
Particle size parametersCircle equivalent diameter, length, width, perimeter, area, max distance, sphere equivalent vol, fiber total length, fiber width
Particle shape parametersAspect ratio, circularity, convexity, elongation, high sensitivity circularity, solidity, fibre elongation, fibre straightness
Integrated Sample DispersionFully automated dispersion with SOP control of dispersion pressure, injection time and settling time
Detector18 MP; 4912 x 3684 pixel colour CCD array; pixel size 1.25 μm x 1.25 μm

Product Overview

The Malvern Morphologi 4 is an easy-to- use, automated particle characterisation tool for the measurement of particle size, shape and count. It is the ideal replacement for costly and time-consuming manual microscopy measurements.

The integrated dry powder disperser simplifies sample preparation by allowing representative sampling and good particle separation. Using compressed air, a small amount of sample is dispersed automatically to ensure any strongly agglomerated materials are evenly distributed while avoiding the damage of fragile particles. Effective dispersion of fibres can also be achieved.

The Morphologi 4 uses a powerful microscope with an integrated high signal to noise CCD camera to provide the highest quality images. Every measurement has calibration checks for camera pixel size and sample illumination intensity providing repeatable and robust methods. The user can also return to a selected particle for a more in depth analysis at higher or lower magnifications.

A choice of accessories supports analysis of samples on microscope slides, in wet suspensions or on membrane filters. The Morphologi 4-ID includes a Raman microprobe, which gains the additional ability to chemically identify particles and foreign contaminants.

The software provides simple operation with automatic selection, targeting and rapid chemical classification of thousands of individual particles. Automated and unattended, the Standard Operating Procedure (SOP) approach delivers substantial time savings by allowing users to get on with other tasks while the instrument completes the measurements.

  • Benefits
  • Applications
  • Accessories

Benefits

Simple automated operation
The integrated dry powder dispersion option ensures representative sampling and optimal spatial separation while avoiding damage of fragile particles.

High quality measurements for both dry and wet samples and particulates on filter membranes
Every measurement has calibration checks for camera pixel size and sample illumination intensity for repeatable and robust methods. The user can return to a selected particle for a more in depth analysis at higher or lower magnifications. ‘Sharp Edge’ analysis enables detection of even low contrast particles. 21 CFR Part 11 software option ensures regulatory compliance.

Saves time and frees up resources

Intuitive software provides simple operation with auto selection, targeting and rapid chemical classification of thousands of individual particles. The SOP approach delivers time savings by allowing for unattended operation.

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Applications

  • Automation of microscopy methods, eg detection of foreign particulates
  • Crystallisation engineering and formulation development
  • Discovery/R&D screening tool with only mg of sample needed
  • Troubleshooting and root cause analysis in manufacturing
  • Validation of QC particle sizing methods, e.g laser diffraction
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Accessories

For analysis of particles in suspension

2-slide and 4-slide holder

Allows a few μL of a particulate suspension to be presented using either the 2-slide or 4-slide holder.

 

 

Wet dispersion cell

Allows between 2 mL and 6 mL of sample for characterising larger suspended particles or where volumetric particle count is important.

 

Thin-path wet cell

It is ideal for applications such as the identification of subvisible particles (upto 100μL) in therapeutics described by guidance in USP <787> and USP <788>.

 

 

25 mm and 47 mm diameter filter holders

Allow samples on filter membranes to be presented directly to the instrument for  analysis.

 

 

 

Fused silica filters and holder

Enable the analysis of filtered samples containing low-contrast particles such as
protein aggregates or contaminant particles.

 

 

Twin 35 mm petri dish holder

Provides an alternative means of measuring suspended particles that may be at
risk of being deformed when dispersed into a cell.

 

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Product Enquiry

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