Malvern Morphologi 4-ID

Malvern Morphologi 4-ID combines automated static imaging for particle size, shape, count with Raman Spectroscopy to enable additional chemical identification analysis.

Malvern Morphologi 4-ID

Malvern Morphologi 4-ID combines automated static imaging for particle size, shape, count with Raman Spectroscopy to enable additional chemical identification analysis.

Manufacturer Malvern Panalytical
Product SeriesMalvern Morphologi
Measurement principleMicroscopy - Image Analysis + Raman Spectroscopy
ApplicationParticle Shape, Count & Chemical ID
Sample typePowders, suspensions, fibres
Particle size range0.5µm to >1300µm
Particle size parametersCircle equivalent diameter, length, width, perimeter, area, max distance, sphere equivalent vol, fiber total length, fiber width
Particle shape parametersAspect ratio, circularity, convexity, elongation, high sensitivity circularity, solidity, fiber elongation, fiber straightness
Integrated sample dispersionFully automated dispersion with SOP control
Detector18 MP; 4912 x 3684 pixel colour CCD array; pixel size 1.25 μm x 1.25 μm

Product Overview

The Malvern Morphologi 4-ID provides a unique capability, combining automated static imaging features of the Morphologi 4 with chemical identification of individual particles using Raman spectroscopy. This fully automated instrument measures particle size, particle shape and chemical identity, all in one platform.

The integrated dry powder disperser simplifies sample preparation by allowing representative sampling and good particle separation. Using compressed air, a small amount of sample is dispersed automatically to ensure any strongly agglomerated materials are evenly distributed while avoiding the damage of fragile particles. Effective dispersion of fibres can also be achieved.

The Morphologi 4-ID uses a powerful microscope with an integrated high signal to noise CCD camera to provide the highest quality images. Particles of interest can be selected based upon size/ shape information from which a Raman spectrum is collected enabling the user to chemically identify specific ingredients or contaminants. Spectra of unknown particles can be directly exported to Bio-Rad’s KnowItAll ®  ID Expert software for comparison against its Raman library containing over 13,000 spectra.

The software provides simple operation with automatic selection, targeting and rapid chemical classification of thousands of individual particles. Automated and unattended, the Standard Operating Procedure (SOP) approach delivers substantial time savings by allowing users to get on with other tasks while the instrument completes the measurements.

  • Benefits
  • Applications
  • Accessories

Benefits

  • Simple automated operation saves time and frees up resources
    Intuitive software provides simple operation with auto selection, targeting and rapid chemical classification of thousands of individual particles. ‘Sharp Edge’ analysis enables detection of even low contrast particles. 21 CFR Part 11 software option ensures regulatory compliance.
  • Fully automated and easy to use with reproducible sample dispersion
    The integrated dry powder dispersion option ensures representative sampling and optimal spatial separation while avoiding damage of fragile particles.
  • Efficient targeting of particles for chemical identification
    Removes operator subjectivity by selecting particles for automated chemical identification based on size and shape and ensures more efficient use of instrument time.
  • Patented Morphologically-Directed Raman Spectroscopy (MDRS) for automated chemical identification and classification
    Morphological imaging combined with a Raman spectrum allows component-specific particle size and shape distributions to be achieved as well as the chemical identification of unknown particulates. By cross-examining a library of reference materials, the unknown materials can be easily characterised.
Make Product Enquiry

Applications

  • Automation of microscopy methods, eg detection and enumeration of foreign particulates
  • Crystallisation engineering and formulation development
  • Discovery/R&D screening tool with only mg of sample needed
  • Particle size of a specific ingredient
  • Contaminant identification using Raman spectroscopy
Make Product Enquiry

Accessories

For analysis of particles in suspension

2-slide and 4-slide holder

Allows a few μL of a particulate suspension to be presented using either the 2-slide or 4-slide holder.

 

 

 

Wet dispersion cell

Allows between 2 mL and 6 mL of sample for characterising larger suspended particles or where volumetric particle count is important.

 

 

Thin-path wet cell

It is ideal for applications such as the identification of subvisible particles (upto 100μL) in therapeutics described by guidance in USP <787> and USP <788>.

 

 

25 mm and 47 mm diameter filter holders

Allow samples on filter membranes to be presented directly to the instrument for  analysis.

 

 

 

Fused silica filters and holder

Enable the analysis of filtered samples containing low-contrast particles such as
protein aggregates or contaminant particles.

 

 

Twin 35 mm petri dish holder

Provides an alternative means of measuring suspended particles that may be at
risk of being deformed when dispersed into a cell.

Make Product Enquiry

Product Enquiry

To enquire about this product, please send through your details below and one of our product specialists will be in touch to discuss your requirements

Required field*

We value your privacy and will not sell or share the details you provide with any other organisation