Demonstration video

Benefits

• Simple automated operation saves time and frees up resources
  Intuitive software provides simple operation with auto selection, targeting and rapid chemical classification of thousands of individual particles. ‘Sharp Edge’ analysis enables detection of even low contrast particles. 21 CFR Part 11 software option ensures regulatory compliance.
• Fully automated and easy to use with reproducible sample dispersion
  The integrated dry powder dispersion option ensures representative sampling and optimal spatial separation while avoiding damage of fragile particles.
• Efficient targeting of particles for chemical identification
  Removes operator subjectivity by selecting particles for automated chemical identification based on size and shape and ensures more efficient use of instrument time.
• Patented Morphologically-Directed Raman Spectroscopy (MDRS) for automated chemical identification and classification
  Morphological imaging combined with a Raman spectrum allows component-specific particle size and shape distributions to be achieved as well as the chemical identification of unknown particulates. By cross-examining a library of reference materials, the unknown materials can be easily characterised.

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Applications

• Automation of microscopy methods, eg detection and enumeration of foreign particulates
• Crystallisation engineering and formulation development
• Discovery/R&D screening tool with only mg of sample needed
• Particle size of a specific ingredient
• Contaminant identification using Raman spectroscopy

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Accessories

For analysis of particles in suspension

2-slide and 4-slide holder

Allows a few μL of a particulate suspension to be presented using either the 2-slide or 4-slide holder.

 

 

 

Wet dispersion cell

Allows between 2 mL and 6 mL of sample for characterising larger suspended particles or where volumetric particle count is important.

 

 

Thin-path wet cell

It is ideal for applications such as the identification of subvisible particles (upto 100μL) in therapeutics described by guidance in USP <787> and USP <788>.

 

 

25 mm and 47 mm diameter filter holders

Allow samples on filter membranes to be presented directly to the instrument for  analysis.

 

 

 

Fused silica filters and holder

Enable the analysis of filtered samples containing low-contrast particles such as
protein aggregates or contaminant particles.

 

 

Twin 35 mm petri dish holder

Provides an alternative means of measuring suspended particles that may be at
risk of being deformed when dispersed into a cell.

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