Product Overview

High pressure homogenisation is an efficient and easy to use technique for cell disruption and liposome/emulsion processing.

The principle is to pump the sample through a valve with a small aperture. The sample goes from very high pressure on the pump side of the valve to atmospheric pressure on the outlet side of the valve. This extreme change of pressure produces very high shear forces on the sample as it exits the valve. The effect on cells is to disrupt their membranes and the effect on liposomes/emulsions is that they are dramatically reduced in size.

The Emulsiflex C3 uses a dynamic homogenising valve. The benefit of a dynamic valve is that the samples are processed at a constant homogenising pressure. This produces very uniform liposomes and micro emulsions with a narrow particle size distribution.

High pressure homogenisation enables liposomes and emulsions to be processed from microns to nanometer sizes. Cell disruption is also very efficient. Most cells are ruptured in a single pass thereby avoiding over processing and protein damage.

The electric motor driven pump provides homogenising pressures up to 30,000 psi (207 MPa).The processing capacity is up to 3 Litres /hr and the flow rate is independent of pressure. It can process samples as small as 10mL.

The dynamic homogenising valve can be exchanged with a high pressure extruder. This enables the extrusion of liposomes or emulsions through membranes of specific pore sizes.

The EmulsiFlex-C3 requires electric power of 220V at 50Hz and a supply of bottled air.