Avestin Emulsiflex C5

The Avestin Emulsiflex C5 is a lab scale, air driven, high pressure homogeniser that rapidly reduces particles and droplets from micron to nanometer sizes.

Avestin Emulsiflex C5

The Avestin Emulsiflex C5 is a lab scale, air driven, high pressure homogeniser that rapidly reduces particles and droplets from micron to nanometer sizes.

Manufacturer Avestin
Product SeriesEmulsiflex
Measurement principleHigh Pressure Homogenisation
ApplicationEmulsion & Liposome Processing
Sample typeDispersion, Emulsions, Liposomes
Homogenising pressureup to 30,000 psi (207 MPa)
Throughput1 to 5 Litres/hr
Minimum sample volume7ml
Valve typedynamic - pneumatically controlled
Temperature controloptional water bath
Extruder optionYes

Product Overview

High pressure homogenisation is an efficient and easy to use technique for cell disruption and liposome/emulsion processing.

The principle is to pump the sample through a valve with a small aperture. The sample goes from very high pressure on the pump side of the valve to atmospheric pressure on the outlet side of the valve. This extreme change of pressure produces very high shear forces on the sample as it exits the valve. The effect on cells is to disrupt their membranes and the effect on liposomes/emulsions is that they are dramatically reduced in size.

The Emulsiflex C5 uses a dynamic homogenising valve. The benefit of a dynamic valve is that the samples are processed at a constant homogenising pressure. This produces very uniform liposomes and micro emulsions with a narrow particle size distribution.

High pressure homogenisation enables liposomes and emulsions to be processed from microns to nanometer sizes. Cell disruption is also very efficient. Most cells are ruptured in a single pass thereby avoiding over processing and protein damage.

The dynamic homogenising valve can be exchanged with a high pressure extruder. This enables the extrusion of liposomes or emulsions through membranes of specific pore sizes.

The Emulsiflex C5 requires a supply of compressed or bottled air. For most emulsions, liposomes and E. coli rupture, an air pressure of 100psi is sufficient.

  • Benefits
  • Applications

Benefits

Efficient and uniform processing
Most cells are ruptured in a single pass avoiding over processing and protein damage.

Liposome processing
Liposomes and emulsions can be processed from micron to nanometer sizes with narrow
particle size distributions.

Air driven, quiet operation and easy to clean
No “O”rings or gaskets in the product path. Valve parts can readily be removed for inspection.

Compact unit
Compact unit that can be immersed in a water bath for temperature control.

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Applications

  • Dispersions: EmulsiFlex homogenisers are involved in the processing of dispersions such as drug dispersions, herb extracts, industrial coatings and pigments
  • Liposomes: AVESTIN’s high pressure homogenisers are used all over the world for liposome research and production.
  • Emulsions/ Cell rupture: Pharmaceutical emulsions and cells such as yeast can be processed to a reduced size and narrow distribution.
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