NanoFlowSizer

Nano emulsions – with inline processing, the droplet size can be monitored in real time and thus the process variables can be modified accordingly to obtain the desirable droplet size.

• Measure emulsions created using high pressure homogenisation in food and pharma industries.
• Measure particle (droplet) size of a lipid nano-emulsion formulation with propofol (anesthetic for Covid-19 intensive care patients).
• Combine with other technologies like an NIR probe for particle size plus chemical composition in solution in real time.

Liposomes – Liposomes have a wide range of industrial applications; such as drug delivery vehicles in medicine, adjuvants in vaccination, signal enhancers in medical diagnostics etc. NanoFlowSizer allows:

• Inline size monitoring of liposomes at different scales (from microliter to liter), using a variety of modules.
• local behavior of the liposomes, such as interactions with the wall, can be tracked.
• Local dynamics and local size phenomena, e.g. depletion, and segregation, that standard DLS can not observe.

Vaccines, mRNA, protein molecules – Controlled and precise manufacturing of drug carrier systems (like the LNP-mRNA COVID-19 vaccines from Moderna and Pfizer) with a constant and narrow size distribution are required to achieve optimum clinical performance.

• Inline measurement of nanoparticle formulations can be used in either development laboratories, pilot plants or commercial operations.
• Production processes of vaccines get direct real time feedback about quality, purity and particle size every 10 seconds.
• Enables continuous nanomedicine manufacturing with the benefit of high quality, high efficiency and lower costs.

Nanoparticle synthesis – Nucleation and growth of particles during their synthesis can be monitored with real time feedback using a static or an inline setup. The NanoFlowSizer is capable of detecting changes in the backscattered intensity over time which are directly related to the concentration and size of nanoparticles in suspension. It can also monitor aggregation of particles.

• Silica, Iron, Titanium dioxide, Gold particles
• Polymers, Inks, Coatings

What is the NanoFlowSizer used for?

The NanoFlowSizer is an in-line particle size analyser designed for real-time monitoring of flowing or dynamic systems directly within a process. It enables continuous monitoring and control of particle size during manufacturing and formulation, and can detect local variations, aggregation, or concentration gradients.

What types of materials can the NanoFlowSizer measure?

NanoFlowSizer is ideal for nanoparticles, emulsions, suspensions and colloidal systems, including pharmaceutical formulations, vaccines, lipid nanoparticles, polymers, inks, coatings and advanced functional materials.

What particle size range does the NanoFlowSizer cover?

The NanoFlowSizer typically measures particles in the nanometre range (approximately 1 to 1,000 nm), making it well suited for applications where tight control of nanoscale size is critical.

How does NanoFlowSizer work?

The NanoFlowSizer uses Spatially Resolved Dynamic Light Scattering (SR-DLS). A laser illuminates the sample and nanoparticles scatter the light as they move under Brownian motion. SR-DLS separates scattered light from different spatial regions within the sample and analyses the intensity fluctuations for each region to calculate diffusion coefficients and hydrodynamic particle size, generating a spatially resolved particle size profile that reveals both average size and any local variations or inhomogeneities.

Can I have a demonstration or free trial of the NanoFlowSizer?

Yes, if a system is available. Contact us for a booking. We can arrange a personalised demo and test your samples within our lab facility in Sydney. Onsite free trials are also available. Contact us or complete a request a demo form to get started.