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Zetasizer

Malvern Panalytical

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Zetasizer Lab is the entry-level particle size and zeta potential analyser with enhanced capabilities while also being cost-effective.
Manufacturer Malvern Panalytical
Product Series Malvern Zetasizer
Measurement principle Dynamic Light Scattering
Application Molecular Weight & Size, Nano Particle Size, Protein Crystallisation, Zeta Potential
Size range 0.3 nm – 10 μm (diameter)
Measurement angle 90°
Sample volume 3 μL
Concentration range 0.1 mg/mL to 40% w/v

The Zetasizer Lab is the entry-level instrument for generating high-quality measurements of particle size and zeta potential, especially for larger sized particles.

Zetasizer Lab is part of the new Zetasizer Advance range which comprises of three core models: Zetasizer Lab, Zetasizer Pro, and Zetasizer Ultra. Each model is available in two variants: a Blue Label version for routine sample investigation and a Red Label version for use with more challenging samples.

Built on the market-leading Zetasizer Nano range, the new Zetasizer Lab delivers enhanced speed and ease of use, accelerating sample throughput and freeing up operator time for other tasks.

Static Light Scattering at 90° provides measurements of molecular weight while M3-PALS technology provides excellent zeta and electrophoretic mobility measurements. The addition of Constant Current Mode for measuring electrophoretic mobility and zeta potential in high conductivity media reduces the likelihood of errors associated with charge screening at higher ion concentrations.

The unique sample-centric workflow of the ZS Xplorer software is designed to simplify and automate analysis to deliver the ultimate in usability and flexibility. A new algorithm called Adaptive Correlation applies intelligent logic to separate data associated with the presence of dust or aggregates, filtering these from the results to give a more representative overall picture of the sample.

Zetasizer Sample Assistant addresses the growing need to scale up to keep pace with the higher throughput requirements by enabling round-the-clock automated sample measurements. It enables researchers to continue obtaining the high-quality data needed for critical decisions, while eliminating the risk of cross-contamination. The accessory will also minimise the requirement for supervision, freeing scientists time for other tasks.

Resources

  • Dynamic Light Scattering (DLS) measures particle and molecule size, from below 1 nm to 10 μm.
  •  Electrophoretic Light Scattering (ELS) measures the zeta potential of particles and molecules, indicating sample stability and/or propensity to aggregate.
  • Sample-centric ZS Xplorer software enables flexible, guided use, and provides assistance as required.
  • The deep-learning empowered Data Quality System assists users in understanding which of their size data might be poor, and why and also suggests how to improve results.
  • Adaptive Correlation produces reliable and repeatable data over twice as quickly, providing a truly representative view of the sample.
  • M3-PALS with Constant Current Mode measures electrophoretic mobility and zeta potential in high conductivity media.
  • On-site upgradeability to either Zetasizer Pro or Zetasizer Ultra models
  • Bioscience and biopharmaceuticals: simple purity and stability screening can assist with formulation development. Time, temperature, pH and shear can all impact biological molecules and cause aggregation, which is detected by Zetasizer instruments.
  • Pharmaceuticals and drug delivery: effective therapeutics must be delivered safely, with dispersion quality and stability being critical quality attributes.  Zetasizer systems can help speed up formulation development and final product development by providing insight earlier in the development pipeline.
  • Paints, inks, and coatings: the stability of formulated nanoparticle suspensions is important, and both size and zeta potential help optimise product performance. Non-invasive back-scatter analysis can be used over a wide concentration range, with no/minimal dilution.
  • Advanced Nanomaterials: Zetasizer instruments’ high sensitivity and low sample volume requirement can help guide in the early research and development phase of advanced materials design for materials like graphene, catalysts, and nanotubes.
  • Food and drink: appearance, stability and flavour emulsions are all influenced by some of the nanoscale properties light scattering can measure –  not only particle size but also particle charge can influence the final consumable product.
  • Consumer products ranging from detergents to cosmetics. Understanding of colloidal stability and control or adjustment of performance parameters helps guide product development.
  • Academia: As an essential analytical instrument in many educational settings and academic research laboratories, tens of thousands of scientific publications attest to the widest range of suitable applications – and the particular ease-of-use and built-in reliability of Zetasizer systems have helped make them the favoured ‘go-to’ tools for rapid ensemble average size as well as zeta potential determination.

Zetasizer Sample Assistant

Download brochure here

Zetasizer Sample Assistant is an automation option that enables users to generate more measurements of particle size, zeta potential, and particle concentration per day, while reducing the need for supervision.

MPT-3 Auto titrator

Designed to automate the measurement of size and zeta potential as a function of pH.

SV-10 Viscometer

Measures viscosity for the conversion of diffusion speed to size, and electrophoretic mobility to zeta potential. Useful for complex dispersants for which there are no available standard literature values for viscosity.

Disposable folded capillary cell

This capillary cell enables contamination-free, high accuracy size, zeta potential and protein mobility measurements in as little as 20 μL of sample. The new capillary shape provides improved repeatability along with enhanced thermal performance.

Low volume disposable sizing cell (Zetasizer Ultra only)

A very low volume (minimum 3 μL) disposable sizing cuvette which extends the size measurement range for the Zetasizer without density-matching of the dispersant.

Universal ‘dip’ cell kit

A reusable solvent resistant cell for the measurement of zeta potential in aqueous and non-aqueous dispersants using polystyrene or glass cuvettes.

High concentration zeta potential cell kit

This high concentration cell enables measurement of the zeta potential of samples with little or no dilution required.

12 mm square glass cuvette

Compatible with both aqueous and non-aqueous solvents and dispersants, and is used for size measurements.

Low-volume quartz cuvette

Holds between 12 μL and 45 μL of sample and is used for size measurements. It is compatible with both aqueous and non-aqueous solvents.

12 mm glass cell

Used for size and zeta potential measurements using the ‘dip’ cell, compatible with both aqueous and non-aqueous solvents and dispersants.

12 mm square polystyrene cuvette

For size measurements, and also for zeta potential measurements when used with the ‘dip’ cell. This cuvette is typically used for samples where cross-contamination might be an issue.

Disposable micro-cuvette

Holds a maximum sample volume of 40 μL. Compatible with both aqueous and non-aqueous solvents and dispersants for size measurements.

What is dynamic light scattering used for?

Dynamic Light Scattering (DLS) is used to measure particle size, zeta potential (particle charge), and molecular size of nanoparticles and macromolecules in suspension. Zetasizer is ideal for a wide range of applications across many industries, including pharmaceuticals, foods, coatings, pigments, colloids, nano materials and mining.

What is the difference between NanoSight (NTA) and Zetasizer (DLS)?

The Zetasizer uses Dynamic Light Scattering (DLS) to provide ensemble-average measurements of particle size, zeta potential, and molecular size, with minimum sample volumes from 3 uL. The NanoSight uses Nanoparticle Tracking Analysis (NTA) to track individual particles, providing size and concentration data and enhanced resolution for polydisperse samples while a fluorescence mode allows differentiation of fluorescing particles.

How does the Zetasizer measure zeta potential?

The Zetasizer Advance range measures zeta potential using M3-PALS (Phase Analysis Light Scattering) technology, with a constant current measurement option for enhanced accuracy.

What particle size range can Zetasizer measure?

The Zetasizer Ultra, Pro and Lab measure particle sizes from 0.3 nm to 15 um; Zeta potential can be measured for particles from 3.8 nm to 100 um across all models.

What sample volume is required for Zetasizer?

The Zetasizer Ultra and Lab require a minimum of 3 uL. The Zetasizer Pro requires a minimum of 12 uL.

What is the Malvern Panalytical Zetasizer used for?

The Zetasizer is used to measure particle size, zeta potential and concentration in liquids. It is widely used to characterise nanoparticles, emulsions, suspensions, liposomes, lipid nanoparticles (LNPs), proteins, polymers and biological samples, across pharmaceutical, biotechnology, food, chemical and materials science applications in research, development and quality control.

What are the key advantages of the Zetasizer compared to other techniques?

The Zetasizer delivers highly repeatable measurements critical for formulation development, QC and regulatory confidence. Intuitive software supports routine measurements as well as advanced analysis. Software options are available to support 21 CFR Part 11 compliant environments. A wide range of accessories allows configuration for everything from basic R&D to advanced QC workflows. Backed by ATA Scientific in Australia and New Zealand with expert local advice, training, and servicing.

Can I get free software updates for the Zetasizer?

Yes, software updates are available free of charge. You can find your software version by clicking the menu button in the upper left corner and selecting About. Updates are available from the Malvern Panalytical website under Zetasizer product support.

Which cuvette should I use with my Zetasizer?

There are many cuvette options for the Zetasizer depending on your application and sample type. Malvern Panalytical provides a cuvette selection guide on their knowledge centre to help you choose the right cell for your measurement.

How important are refractive index and absorption values for nanoparticle measurements?

You do not need the particle refractive index (RI) for a basic DLS measurement of the intensity-based size distribution. However, if you need to report a volume-based or number-based distribution, the particle refractive index and dispersant refractive index are required to convert the intensity-weighted results.

How much does a Zetasizer DLS system cost?

The Zetasizer comes in many configurations depending on your measurement needs. Contact us for a quote and our team will recommend the best options for your application and budget.

Can I have a demonstration or free trial of the Zetasizer?

Yes, contact us for a booking. We can arrange a personalised demo and test your samples within our lab facility in Sydney. Onsite free trials are also available. Contact us or complete a request a demo form to get started.

The Zetasizer Pro is the most versatile system for the measurement of particle and molecular size and electrophoretic mobility and zeta potential of nanoparticles.
Manufacturer Malvern Panalytical
Product Series Malvern Zetasizer
Measurement principle Dynamic Light Scattering
Application Molecular Weight & Size, Nano Particle Size, Protein Crystallisation
Size range 0.3 nm – 10 μm (diameter)
Measurement angle 173°, 13°
Sample volume 12 μL
Sample concentration range 0.1 mg/mL to 40% w/v

The Zetasizer Pro is the most versatile instrument for the measurements of molecular size, particle size, electrophoretic mobility and zeta potential.

Zetasizer Pro is part of the new Zetasizer Advance range which comprises of three core models: Zetasizer Lab, Zetasizer Pro, and Zetasizer Ultra. Each model is available in two variants: a Blue Label version for routine sample investigation and a Red Label version for use with more challenging samples.

Built on the market-leading Zetasizer Nano range, the new Zetasizer Pro delivers enhanced speed and ease of use, accelerating sample throughput and freeing up operator time for other tasks.

Non-Invasive Back Scatter (NIBS®) technology enables the precise measurement of particle and molecular size over an extended concentration range while M3-PALS technology provides excellent zeta and electrophoretic mobility measurements. The addition of Constant Current Mode for measuring electrophoretic mobility and zeta potential in high conductivity media reduces the likelihood of errors associated with charge screening at higher ion concentrations.

The unique sample-centric workflow of the ZS Xplorer software is designed to simplify and automate analysis to deliver the ultimate in usability and flexibility.  A new algorithm called Adaptive Correlation applies intelligent logic to separate data associated with the presence of dust or aggregates, filtering these from the results to give a more representative overall picture of the sample.

Zetasizer Sample Assistant addresses the growing need to scale up to keep pace with the higher throughput requirements by enabling round-the-clock automated sample measurements. It enables researchers to continue obtaining the high-quality data needed for critical decisions, while eliminating the risk of cross-contamination. The accessory will also minimise the requirement for supervision, freeing scientists time for other tasks.

Resources

  • Dynamic Light Scattering (DLS) measures particle and molecule size, from below 1 nm to 10 μm.
  •  Electrophoretic Light Scattering (ELS) measures the zeta potential of particles and molecules, indicating sample stability and/or propensity to aggregate.
  • Sample-centric ZS Xplorer software enables flexible, guided use, and provides assistance as required.
  • The deep-learning empowered Data Quality System assists users in understanding which of their size data might be poor, and why and also suggests how to improve results.
  • Optical filter wheel offers a fluorescence filter and both vertical and horizontal polarisers for analytical flexibility.
  • Adaptive Correlation produces reliable and repeatable data over twice as quickly, providing a truly representative view of the sample.
  • NIBS (Non-Invasive Back-Scatter) technology maximises the dynamic range, providing the highest sensitivity for even the most concentrated samples.
  • M3-PALS with Constant Current Mode measures electrophoretic mobility and zeta
    potential in high conductivity media.
  • Bioscience and biopharmaceuticals: simple purity and stability screening can assist with formulation development. Time, temperature, pH and shear can all impact biological molecules and cause aggregation, which is detected by Zetasizer instruments.
  • Pharmaceuticals and drug delivery: effective therapeutics must be delivered safely, with dispersion quality and stability being critical quality attributes.  Zetasizer systems can help speed up formulation development and final product development by providing insight earlier in the development pipeline.
  • Paints, inks, and coatings: the stability of formulated nanoparticle suspensions is important, and both size and zeta potential help optimise product performance. Non-invasive back-scatter analysis can be used over a wide concentration range, with no/minimal dilution.
  • Advanced Nanomaterials: Zetasizer instruments’ high sensitivity and low sample volume requirement can help guide in the early research and development phase of advanced materials design for materials like graphene, catalysts, and  nanotubes.
  • Food and drink: appearance, stability and flavour emulsions are all influenced by some of the nanoscale properties light scattering can measure –  not only particle size but also particle charge, can influence the final consumable product.
  • Consumer products ranging from detergents to cosmetics. Understanding of colloidal stability and control or adjustment of performance parameters helps guide product development.
  • Academia: As an essential analytical instrument in many educational settings and academic research laboratories, tens of thousands of scientific publications attest to the widest range of suitable applications – and the particular ease-of-use and built-in reliability of Zetasizer systems have helped make them the favoured ‘go-to’ tools for rapid ensemble average size as well as zeta potential determination.

Zetasizer Sample Assistant

Download brochure here

Zetasizer Sample Assistant is an automation option that enables users to generate more measurements of particle size, zeta potential, and particle concentration per day, while reducing the need for supervision.

MPT-3 Auto titrator

Designed to automate the measurement of size and zeta potential as a function of pH.

SV-10 Viscometer

Measures viscosity for the conversion of diffusion speed to size, and electrophoretic mobility to zeta potential. Useful for complex dispersants for which there are no available standard literature values for viscosity.

Disposable folded capillary cell

This capillary cell enables contamination-free, high accuracy size, zeta potential and protein mobility measurements in as little as 20 μL of sample. The new capillary shape provides improved repeatability along with enhanced thermal performance.

Low volume disposable sizing cell (Zetasizer Ultra only)

A very low volume (minimum 3 μL) disposable sizing cuvette which extends the size measurement range for the Zetasizer without density-matching of the dispersant.

Universal ‘dip’ cell kit

A reusable solvent resistant cell for the measurement of zeta potential in aqueous and non-aqueous dispersants using polystyrene or glass cuvettes.

High concentration zeta potential cell kit

This high concentration cell enables measurement of the zeta potential of samples with little or no dilution required.

12 mm square glass cuvette

Compatible with both aqueous and non-aqueous solvents and dispersants, and is used for size measurements.

Low-volume quartz cuvette

Holds between 12 μL and 45 μL of sample and is used for size measurements. It is compatible with both aqueous and non-aqueous solvents.

12 mm glass cell

Used for size and zeta potential measurements using the ‘dip’ cell, compatible with both aqueous and non-aqueous solvents and dispersants.

12 mm square polystyrene cuvette

For size measurements, and also for zeta potential measurements when used with the ‘dip’ cell. This cuvette is typically used for samples where cross-contamination might be an issue.

Disposable micro-cuvette

Holds a maximum sample volume of 40 μL. Compatible with both aqueous and non-aqueous solvents and dispersants for size measurements.

What is dynamic light scattering used for?

Dynamic Light Scattering (DLS) is used to measure particle size, zeta potential (particle charge), and molecular size of nanoparticles and macromolecules in suspension. Zetasizer is ideal for a wide range of applications across many industries, including pharmaceuticals, foods, coatings, pigments, colloids, nano materials and mining.

What is the difference between NanoSight (NTA) and Zetasizer (DLS)?

The Zetasizer uses Dynamic Light Scattering (DLS) to provide ensemble-average measurements of particle size, zeta potential, and molecular size, with minimum sample volumes from 3 uL. The NanoSight uses Nanoparticle Tracking Analysis (NTA) to track individual particles, providing size and concentration data and enhanced resolution for polydisperse samples while a fluorescence mode allows differentiation of fluorescing particles.

How does the Zetasizer measure zeta potential?

The Zetasizer Advance range measures zeta potential using M3-PALS (Phase Analysis Light Scattering) technology, with a constant current measurement option for enhanced accuracy.

What particle size range can Zetasizer measure?

The Zetasizer Ultra, Pro and Lab measure particle sizes from 0.3 nm to 15 um; Zeta potential can be measured for particles from 3.8 nm to 100 um across all models.

What sample volume is required for Zetasizer?

The Zetasizer Ultra and Lab require a minimum of 3 uL. The Zetasizer Pro requires a minimum of 12 uL.

What is the Malvern Panalytical Zetasizer used for?

The Zetasizer is used to measure particle size, zeta potential and concentration in liquids. It is widely used to characterise nanoparticles, emulsions, suspensions, liposomes, lipid nanoparticles (LNPs), proteins, polymers and biological samples, across pharmaceutical, biotechnology, food, chemical and materials science applications in research, development and quality control.

What are the key advantages of the Zetasizer compared to other techniques?

The Zetasizer delivers highly repeatable measurements critical for formulation development, QC and regulatory confidence. Intuitive software supports routine measurements as well as advanced analysis. Software options are available to support 21 CFR Part 11 compliant environments. A wide range of accessories allows configuration for everything from basic R&D to advanced QC workflows. Backed by ATA Scientific in Australia and New Zealand with expert local advice, training, and servicing.

Can I get free software updates for the Zetasizer?

Yes, software updates are available free of charge. You can find your software version by clicking the menu button in the upper left corner and selecting About. Updates are available from the Malvern Panalytical website under Zetasizer product support.

Which cuvette should I use with my Zetasizer?

There are many cuvette options for the Zetasizer depending on your application and sample type. Malvern Panalytical provides a cuvette selection guide on their knowledge centre to help you choose the right cell for your measurement.

How important are refractive index and absorption values for nanoparticle measurements?

You do not need the particle refractive index (RI) for a basic DLS measurement of the intensity-based size distribution. However, if you need to report a volume-based or number-based distribution, the particle refractive index and dispersant refractive index are required to convert the intensity-weighted results.

How much does a Zetasizer DLS system cost?

The Zetasizer comes in many configurations depending on your measurement needs. Contact us for a quote and our team will recommend the best options for your application and budget.

Can I have a demonstration or free trial of the Zetasizer?

Yes, contact us for a booking. We can arrange a personalised demo and test your samples within our lab facility in Sydney. Onsite free trials are also available. Contact us or complete a request a demo form to get started.

The Zetasizer Ultra, the most advanced light scattering system, delivers enhanced resolution, speed and ease-of-use for the measurement of particle and molecular size, particle charge and particle concentration.
Manufacturer Malvern Panalytical
Product Series Malvern Zetasizer
Measurement principle Dynamic Light Scattering, Multi-Angle Dynamic Light Scattering (MADLS)
Application Molecular Weight & Size, Nano Particle Size, Protein Crystallisation, Zeta Potential
Size range 0.3 nm – 10 μm (diameter)
Measurement angle 173°, 13°, 90°
Sample volume 3μL
Particle concentration range 1 x 10⁸ – 1 x 10¹² particles/mL
Sample concentration range 0.1 mg/mL to 40% w/v

The Malvern Zetasizer Ultra is the most advanced system for the measurement of particle and molecular size, particle charge and particle concentration.

Zetasizer Ultra is the highest performance system in the new Zetasizer Advance range which comprises of three core models: Zetasizer Lab, Zetasizer Pro, and Zetasizer Ultra. Each model is available in two variants: a Blue Label version for routine sample investigation and a Red Label version for use with more challenging samples.

Built on the market-leading Zetasizer Nano range, the new Zetasizer Ultra delivers enhanced speed and ease of use, accelerating sample throughput and freeing up operator time for other tasks.

Alongside the patented Non-Invasive Back-Scatter (NIBS) technology, the Zetasizer Ultra offers Multi-Angle Dynamic Light Scattering (MADLS®) which automates multiple-angle size measurements, providing higher resolution and more complete particle size distributions. MADLS also enables calibration-free particle concentration analysis for a wide range of materials, resolving the individual concentrations of different size populations to provide even greater insight into your samples.

The new disposable capillary sizing cell provides the ultimate in non-destructive, low volume (3μl) analysis, extending the upper range to 10μm and delivering high-quality data while reducing cost.

The Zetasizer Ultra is controlled by user-friendly ZS Xplorer software, introducing new sample-centric workflows, which make method design and data analysis more straightforward.  A new algorithm called Adaptive Correlation applies intelligent logic to separate data associated with the presence of dust or aggregates, filtering these from the results to give a more representative overall picture of the sample. This is supported by integrated, deep-learning empowered data quality guidance, offering the user instant feedback on their results and providing actionable advice.

Zetasizer Sample Assistant addresses the growing need to scale up to keep pace with the higher throughput requirements by enabling round-the-clock automated sample measurements. It enables researchers to continue obtaining the high-quality data needed for critical decisions, while eliminating the risk of cross-contamination. The accessory will also minimise the requirement for supervision, freeing scientists time for other tasks.

Resources

  • Multi-Angle Dynamic Light Scattering (MADLS) for high resolution angle-independent size measurements offers greater insight into the size distribution of your sample.
  • Disposable capillary sizing cell provides the ultimate in non-destructive, low volume (down to 3 μL) analysis, with an upper size range that extends to 10 μm.
  • Simple, calibration-free measurement of particle concentration in homogeneous sample types, covering a wide range of materials.
  • Electrophoretic Light Scattering (ELS) measures the zeta potential of particles and molecules, indicating sample stability and/or propensity to aggregate.
  • Sample-centric ZS Xplorer software enables flexible, guided use, and the capability to build complex methods with ease.
  • Optical filter wheel offers a fluorescence filter and both vertical and horizontal polarisers for analytical flexibility.
  • NIBS (Non-Invasive Back-Scatter) technology maximises the dynamic range, providing the highest sensitivity for even the most concentrated samples
  • The deep-learning empowered Data Quality System assists users in understanding which of their size data might be poor, and why. This intelligent neural network system also suggests how to improve results.
  • Adaptive Correlation produces reliable and repeatable data over twice as quickly, providing a truly representative view of the sample.
  • M3-PALS with Constant Current Mode measures electrophoretic mobility and zeta potential in high conductivity media.
  • Bioscience and biopharmaceuticals: simple purity and stability screening can assist with formulation development. Time, temperature, pH and shear can all impact biological molecules and cause aggregation, which is detected by Zetasizer instruments.
  • Pharmaceuticals and drug delivery: effective therapeutics must be delivered safely, with dispersion quality and stability being critical quality attributes.  Zetasizer systems can help speed up formulation development and final product development by providing insight earlier in the development pipeline.
  • Paints, inks, and coatings: the stability of formulated nanoparticle suspensions is important, and both size and zeta potential help optimise product performance. Non-invasive back-scatter analysis can be used over a wide concentration range, with no/minimal dilution.
  • Advanced Nanomaterials: Zetasizer instruments’ high sensitivity and low sample volume requirement can help guide in the early research and development phase of advanced materials design for materials like graphene, catalysts, and nanotubes.
  • Food and drink: appearance, stability and flavour emulsions are all influenced by some of the nanoscale properties light scattering can measure –  not only particle size but also particle charge can influence the final consumable product.
  • Consumer products ranging from detergents to cosmetics. Understanding of colloidal stability and control or adjustment of performance parameters helps guide product development.
  • Academia: As an essential analytical instrument in many educational settings and academic research laboratories, tens of thousands of scientific publications attest to the widest range of suitable applications – and the particular ease-of-use and built-in reliability of Zetasizer systems have helped make them the favoured ‘go-to’ tools for rapid ensemble average size as well as zeta potential determination.

Zetasizer Sample Assistant

Download brochure here

Zetasizer Sample Assistant is an automation option that enables users to generate more measurements of particle size, zeta potential, and particle concentration per day, while reducing the need for supervision.

MPT-3 Auto titrator

Designed to automate the measurement of size and zeta potential as a function of pH.

SV-10 Viscometer

Measures viscosity for the conversion of diffusion speed to size, and electrophoretic mobility to zeta potential. Useful for complex dispersants for which there are no available standard literature values for viscosity.

Disposable folded capillary cell

This capillary cell enables contamination-free, high accuracy size, zeta potential and protein mobility measurements in as little as 20 μL of sample. The new capillary shape provides improved repeatability along with enhanced thermal performance.

Low volume disposable sizing cell (Zetasizer Ultra only)

A very low volume (minimum 3 μL) disposable sizing cuvette which extends the size measurement range for the Zetasizer without density-matching of the dispersant.

Universal ‘dip’ cell kit

A reusable solvent resistant cell for the measurement of zeta potential in aqueous and non-aqueous dispersants using polystyrene or glass cuvettes.

High concentration zeta potential cell kit

This high concentration cell enables measurement of the zeta potential of samples with little or no dilution required.

12 mm square glass cuvette

Compatible with both aqueous and non-aqueous solvents and dispersants, and is used for size measurements.

Low-volume quartz cuvette

Holds between 12 μL and 45 μL of sample and is used for size measurements. It is compatible with both aqueous and non-aqueous solvents.

12 mm glass cell

Used for size and zeta potential measurements using the ‘dip’ cell, compatible with both aqueous and non-aqueous solvents and dispersants.

12 mm square polystyrene cuvette

For size measurements, and also for zeta potential measurements when used with the ‘dip’ cell. This cuvette is typically used for samples where cross-contamination might be an issue.

Disposable micro-cuvette

Holds a maximum sample volume of 40 μL. Compatible with both aqueous and non-aqueous solvents and dispersants for size measurements.

What is dynamic light scattering used for?

Dynamic Light Scattering (DLS) is used to measure particle size, zeta potential (particle charge), and molecular size of nanoparticles and macromolecules in suspension. Zetasizer is ideal for a wide range of applications across many industries, including pharmaceuticals, foods, coatings, pigments, colloids, nano materials and mining.

What is the difference between NanoSight (NTA) and Zetasizer (DLS)?

The Zetasizer uses Dynamic Light Scattering (DLS) to provide ensemble-average measurements of particle size, zeta potential, and molecular size, with minimum sample volumes from 3 uL. The NanoSight uses Nanoparticle Tracking Analysis (NTA) to track individual particles, providing size and concentration data and enhanced resolution for polydisperse samples while a fluorescence mode allows differentiation of fluorescing particles.

How does the Zetasizer measure zeta potential?

The Zetasizer Advance range measures zeta potential using M3-PALS (Phase Analysis Light Scattering) technology, with a constant current measurement option for enhanced accuracy.

What particle size range can Zetasizer measure?

The Zetasizer Ultra, Pro and Lab measure particle sizes from 0.3 nm to 15 um; Zeta potential can be measured for particles from 3.8 nm to 100 um across all models.

What sample volume is required for Zetasizer?

The Zetasizer Ultra and Lab require a minimum of 3 uL. The Zetasizer Pro requires a minimum of 12 uL.

What is the Malvern Panalytical Zetasizer used for?

The Zetasizer is used to measure particle size, zeta potential and concentration in liquids. It is widely used to characterise nanoparticles, emulsions, suspensions, liposomes, lipid nanoparticles (LNPs), proteins, polymers and biological samples, across pharmaceutical, biotechnology, food, chemical and materials science applications in research, development and quality control.

What are the key advantages of the Zetasizer compared to other techniques?

The Zetasizer delivers highly repeatable measurements critical for formulation development, QC and regulatory confidence. Intuitive software supports routine measurements as well as advanced analysis. Software options are available to support 21 CFR Part 11 compliant environments. A wide range of accessories allows configuration for everything from basic R&D to advanced QC workflows. Backed by ATA Scientific in Australia and New Zealand with expert local advice, training, and servicing.

Can I get free software updates for the Zetasizer?

Yes, software updates are available free of charge. You can find your software version by clicking the menu button in the upper left corner and selecting About. Updates are available from the Malvern Panalytical website under Zetasizer product support.

Which cuvette should I use with my Zetasizer?

There are many cuvette options for the Zetasizer depending on your application and sample type. Malvern Panalytical provides a cuvette selection guide on their knowledge centre to help you choose the right cell for your measurement.

How important are refractive index and absorption values for nanoparticle measurements?

You do not need the particle refractive index (RI) for a basic DLS measurement of the intensity-based size distribution. However, if you need to report a volume-based or number-based distribution, the particle refractive index and dispersant refractive index are required to convert the intensity-weighted results.

How much does a Zetasizer DLS system cost?

The Zetasizer comes in many configurations depending on your measurement needs. Contact us for a quote and our team will recommend the best options for your application and budget.

Can I have a demonstration or free trial of the Zetasizer?

Yes, contact us for a booking. We can arrange a personalised demo and test your samples within our lab facility in Sydney. Onsite free trials are also available. Contact us or complete a request a demo form to get started.

Variant comparison

Zetasizer Lab

  • Classic side scatter particle size and zeta potential analyser
  • Classic 90° DLS
  • Size range: 0.3 nm to 15 μm

Zetasizer Pro

  • High performance, versatile and robust particle size and zeta potential analyser
  • Non-Invasive Back Scatter DLS (NIBS)
  • Size range: 0.3 nm to 10 μm

Zetasizer Ultra

  • Most advanced light scattering system for particle size and zeta potential
  • Classic 90° DLS ; Non-Invasive Back Scatter DLS (NIBS) ; Multi-Angle Dynamic Light Scattering (MADLS)
  • Size range: 0.3 nm to 15 μm
  • Particle concentration / titer

 

Zetasizer Lab Zetasizer Pro Zetasizer Ultra
Classic side scatter particle size and zeta potential analyser High performance, versatile and robust Most advanced light scattering system
Size range

0.3 nm to 15 μm

Size range

0.3 nm to 10 μm

Size range

0.3 nm to 15 μm

Static light scattering Static light scattering Static light scattering
Classic 90° DLS Classic 90° DLS
Non-Invasive Back Scatter DLS (NIBS) Non-Invasive Back Scatter DLS (NIBS)
Multi-Angle Dynamic Light Scattering (MADLS)
Minimum volume

3 μL

Minimum volume

12 μL

Minimum volume

3 μL

Zeta potential Zeta potential Zeta potential
Molecular weight Molecular weight Molecular weight
Particle concentration / titer: Red Label only
Zeta potential size range

3.8 nm to 100 μm

Zeta potential size range

3.8 nm to 100 μm

Zeta potential size range

3.8 nm to 100 μm

21 CFR part 11 compliant software

Optional

21 CFR part 11 compliant software

Optional

21 CFR part 11 compliant software

Optional

Automation – Zetasizer sample assistant option Automation – Zetasizer sample assistant option Automation – Zetasizer sample assistant option

Zetasizer

Customer installations

UNSW

Zetasizer

The UNSW, Faculty of Medicine has installed their new Malvern Panalytical Zetasizer Pro, dynamic light scattering system. The Zetasizer delivers enhanced resolution, speed and ease-of-use for the measurement of particle and molecular size, particle charge and particle concentration. These capabilities are key to the group’s research that spans biomedical research to help solve complex and important health challenges like cancer, infectious disease, cardiovascular disease and mental health.

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University of Sydney

Zetasizer

The University of Sydney, School of Chemical and Biomolecular Engineering has installed their new Theta Flex contact angle meter and Malvern Zetasizer Ultra, dynamic light scattering system. The Zetasizer delivers enhanced resolution, speed and ease-of-use for the measurement of particle and molecular size, particle charge and particle concentration. These capabilities are key to the group’s research that spans food, environmental, biomolecular and cell engineering and chemical processes and innovation.

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Sanitarium

Zetasizer

Sanitarium Health Food Company has recently installed their new Malvern Zetasizer Pro. Still 100% Australian owned, the company which was founded in 1898 started making health foods from a small bakery in Melbourne. Sanitarium plans to use the Zetasizer to ensure plant-based foods are processed only as much as needed for optimal nutrition, taste, convenience and safety.

About the lab

University of Sydney

Zetasizer

The University of Sydney, School of Chemistry has installed their Malvern Zetasizer Ultra Red. The group is working to produce complex and multifunctional nano-scale materials for applications in catalysis, energy, sensing and nanomedicine.

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University of Newcastle

Zetasizer

The University of Newcastle has installed their new Malvern MPT-3 autotitrator with their Zetasizer Ultra, which is designed to automate zeta and/or particle size measurements as a function of pH. The MPT-3 autotitrator will help the group study new technologies to remediate inorganic contamination (heavy metals, fluorides, cyanides etc) of ground water and aid in their design and implementation.

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