What is dynamic light scattering used for?
Dynamic Light Scattering (DLS) is used to measure particle size, zeta potential (particle charge), and molecular size of nanoparticles and macromolecules in suspension. Zetasizer is ideal for a wide range of applications across many industries, including pharmaceuticals, foods, coatings, pigments, colloids, nano materials and mining.
What is the difference between NanoSight (NTA) and Zetasizer (DLS)?
The Zetasizer uses Dynamic Light Scattering (DLS) to provide ensemble-average measurements of particle size, zeta potential, and molecular size, with minimum sample volumes from 3 uL. The NanoSight uses Nanoparticle Tracking Analysis (NTA) to track individual particles, providing size and concentration data and enhanced resolution for polydisperse samples while a fluorescence mode allows differentiation of fluorescing particles.
How does the Zetasizer measure zeta potential?
The Zetasizer Advance range measures zeta potential using M3-PALS (Phase Analysis Light Scattering) technology, with a constant current measurement option for enhanced accuracy.
What particle size range can Zetasizer measure?
The Zetasizer Ultra, Pro and Lab measure particle sizes from 0.3 nm to 15 um; Zeta potential can be measured for particles from 3.8 nm to 100 um across all models.
What sample volume is required for Zetasizer?
The Zetasizer Ultra and Lab require a minimum of 3 uL. The Zetasizer Pro requires a minimum of 12 uL.
What is the Malvern Panalytical Zetasizer used for?
The Zetasizer is used to measure particle size, zeta potential and concentration in liquids. It is widely used to characterise nanoparticles, emulsions, suspensions, liposomes, lipid nanoparticles (LNPs), proteins, polymers and biological samples, across pharmaceutical, biotechnology, food, chemical and materials science applications in research, development and quality control.
What are the key advantages of the Zetasizer compared to other techniques?
The Zetasizer delivers highly repeatable measurements critical for formulation development, QC and regulatory confidence. Intuitive software supports routine measurements as well as advanced analysis. Software options are available to support 21 CFR Part 11 compliant environments. A wide range of accessories allows configuration for everything from basic R&D to advanced QC workflows. Backed by ATA Scientific in Australia and New Zealand with expert local advice, training, and servicing.
Can I get free software updates for the Zetasizer?
Yes, software updates are available free of charge. You can find your software version by clicking the menu button in the upper left corner and selecting About. Updates are available from the Malvern Panalytical website under Zetasizer product support.
Which cuvette should I use with my Zetasizer?
There are many cuvette options for the Zetasizer depending on your application and sample type. Malvern Panalytical provides a cuvette selection guide on their knowledge centre to help you choose the right cell for your measurement.
How important are refractive index and absorption values for nanoparticle measurements?
You do not need the particle refractive index (RI) for a basic DLS measurement of the intensity-based size distribution. However, if you need to report a volume-based or number-based distribution, the particle refractive index and dispersant refractive index are required to convert the intensity-weighted results.
How much does a Zetasizer DLS system cost?
The Zetasizer comes in many configurations depending on your measurement needs. Contact us for a quote and our team will recommend the best options for your application and budget.
Can I have a demonstration or free trial of the Zetasizer?
Yes, contact us for a booking. We can arrange a personalised demo and test your samples within our lab facility in Sydney. Onsite free trials are also available. Contact us or complete a request a demo form to get started.