NanoAssemblr Spark

NanoAssemblr Spark enables the manufacture of ultra-low nanoparticle volumes between 25 – 250 μL in less than 10 seconds, which is ideal for low-cost formulation of scarce materials.

NanoAssemblr Spark

NanoAssemblr Spark enables the manufacture of ultra-low nanoparticle volumes between 25 – 250 μL in less than 10 seconds, which is ideal for low-cost formulation of scarce materials.

Manufacturer Precision Nanosystems
Product Series NanoAssemblr platform
Measurement principle Emulsion and Liposome Processing
Application Nanoparticle formulation
Formulation VolumeManufactures 25 µL – 250 µL per run

Product Overview

The NanoAssemblr Spark is designed to accelerate the development of ultra-low volume nanoparticle drug formulations for R&D. Using proprietary microfluidics technology to promote the self-assembly of uniform particles, the Spark enables the controlled and reproducible production of 25 – 250 µL nanoparticles in less than 10 seconds. By ensuring yields nearing 100%, the Spark is ideal for screening novel nanoparticle formulations that use scarce or expensive nucleic acid constructs and nanoparticle excipients.

Conventional approaches to nanoparticle synthesis employ turbulent mixing, which is difficult to control and highly variant across points in space and time. In contrast, NanoAssemblr microfluidic mixers exploit the physics of confined fluid flow to achieve non-turbulent mixing which is highly uniform throughout the mixing volume, and highly reproducible at any given time. Every particle is manufactured under the same localised conditions that maximise drug loading and particle quality.

The NanoAssemblr Spark provides researchers more convenient and reproducible formulations for screening of active pharmaceutical ingredients (APIs) and particle excipients at the micro-litre scale.

One step formulation and push button operation: Payload dilution buffer and nanoparticle components are pipetted into the Spark Cartridge wells. The cartridge is inserted into the Spark where automated mixing is initiated at the push of a button.

  • Benefits
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Particle Size Control: Combining reproducible microfluidics with precise fluid injection allows users to efficiently find and dial-in the optimal conditions for nanoparticle formation.

Efficient Drug Loading: Improved drug loading or encapsulation efficiency compared to conventional methods.

Scalable Production: The continuous flow microfluidic process can be scaled up by increasing total volume injected through a single mixer, or by employing multiple mixer in parallel without affecting the underlying conditions of nano particle synthesis. This allows formulations to be optimised at bench scales, and scaled up with little to no re-optimisation at each change in batch size.

Versatile: Suitable for creating a variety of different particles including:
• Biodegradable polymer nanoparticles (ex: PLGA)
• Amphiphilic block co-polymer micelles (ex: PEG-PLA)
• Dendrimer nanoparticles
• Polymer-drug conjugates
• Nucleic acid Lipid Nanoparticles (LNP)
• Lipsomes, Emulsions, Organic/ Inorganic Nanoparticles


Applications and types of formulations include:
• Gene delivery and screening
• Nanoparticle design and screening
• Targeted delivery of small molecules
• Drug development
• Lipid nanoparticles
• Liposomes
• Polymeric nanoparticles


Spark Cartridges and Formulation Kits

Cartridges are available for in-house particle formulation
R&D. The cartridge uses microfluidic channels for mixing and encapsulation of payload.

Neuro9 siRNA Spark Kit
Neuro9 kits contain everything you need to encapsulate 2 nmol or 5 nmol siRNA into clinically validated lipid nanoparticle (LNP) delivery systems. Kits include a proprietary ionizable cationic lipid and have been optimised for the delivery of siRNA into primary cells such as primary neurons and astrocytes.

GENVOY-ILM T Cell kit for mRNA
The GenVoy-ILM T Cell Kit for mRNA is an LNP reagent mix optimized for the delivery of mRNA into activated primary human T cells using mRNA-LNP.




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