NanoAssemblr Ignite

NanoAssemblr Ignite uses exclusive NxGen microfluidic mixing technology to allow commercial scale manufacturing of nanomedicines through a single mixer.

NanoAssemblr Ignite

NanoAssemblr Ignite uses exclusive NxGen microfluidic mixing technology to allow commercial scale manufacturing of nanomedicines through a single mixer.

Manufacturer Precision Nanosystems
Product SeriesNanoAssemblr platform
Measurement principleEmulsion and Liposome Processing
ApplicationNanoparticle formulation
Temperture controlUp to 75°C
Formulation VolumeUp to 20mL non-diluted, and up to 50mL diluted

Product Overview

The NanoAssemblr Ignite is a nano particle synthesis system that enables the rapid, reproducible, and scalable manufacture of next generation nano particle formulations for the targeted delivery of therapeutic and diagnostic agents to cells and tissues. It is particularly designed for novel nano particles that would be difficult to make with alternative manufacturing methods.

The NanoAssemblr Ignite uses proprietary NxGen scalable continuous-flow microfluidic technology designed exclusively for nanomedicine development. Using controlled mixing it enables users to reproducibly manufacture the highest quality drug products through a single mixer across scales, from mL / min to L / h. NxGen allows time-invariant particle formation to ensure the most reproducible results for a wide range of particle types.

The NanoAssemblr Ignite enables rapid benchtop scale development of nanoparticle based RNA, DNA, CRISPR, small molecule and protein therapeutics.  Optimised drug products are predictably scaled to advanced preclinical and clinical scale with the NxGen technology on the NanoAssemblr Blaze and GMP Systems.

 

 

  • BENEFITS
  • APPLICATIONS
  • ACCESSORIES

BENEFITS

HIGH REPRODUCIBILITY
Advanced microfluidics in an automated system removes batch-to-batch and user-to-user variability.

INTUITIVE WORKFLOW
Easy setup with touch screen interface, saved recipes and a single-use fluid path that eliminates priming and cleaning enables a streamlined workflow.

CONTROLLED ASSEMBLY
Tune particle size with precise control over fluid flow rates

NON-TURBULENT MIXING
This differs from turbulent mixing where collisions are used to speed mixing. These are extremely dependent on geometric and velocity profiles which differ at scale.

VERSATILE
Formulate small molecules, peptides, and nucleic acids into lipid, polymer or hybrid nanoparticles, and more.

SPEEDY AND EFFICIENT
Formulation runs require less than a minute. Over 50 formulations can be completed in a day for rapid optimization.

FROM BENCH TO COMMERCIAL SCALE
The NxGen mixer uses precisely controlled mixing to reproducibly generate optimal particles through a single mixer across scales. Easily scale between 1mL and 20mL formulations on the Ignite. Optimised formulations can be predictably scaled to advanced preclinical and clinical scale with Blaze and GMP Systems with NxGen technology.

APPLICATIONS

Gene delivery via high in vivo cell transfection efficiency
Nanoparticle design
Drug development
Lipid nanoparticles formulation
Liposome encapsulation
Polymeric nanoparticles

ACCESSORIES

 

 

 

 

 

Ignite cartridges are single-use. No priming or cleaning required for an efficient work flow. Ignite cartridges are compatible with a wide range of solvents to make a diverse array of nanomedicine formulations. 

NxGen Ignite cartridges are also available with automated in-line dilution of the nanoparticles to allow modelling of the processes that will be required for future GMP production.

Product Enquiry

To enquire about this product, please send through your details below and one of our product specialists will be in touch to discuss your requirements.

 

Please note, information requests are only applicable to Australia, New Zealand, Papua New Guinea and Fiji.

Required field*