02 9541 3500NanoAssemblr Ignite+
NanoAssemblr Ignite+ builds on the features of Ignite with additional capabilities, enabling small-scale de-risking of large-scale systems and initiating process development activities using simple, low-volume workflows.
NanoAssemblr Ignite+
NanoAssemblr Ignite+ builds on the features of Ignite with additional capabilities, enabling small-scale de-risking of large-scale systems and initiating process development activities using simple, low-volume workflows.
| Manufacturer | Precision Nanosystems |
|---|---|
| Product Series | NanoAssemblr platform |
| Measurement principle | Emulsion and Liposome Processing |
| Application | Nanoparticle formulation |
| Temperature control | Up to 65 °C |
| Formulation Volume | 60 mL non-diluted, up to 90 mL diluted |
| Flow Rate | 0.1 mL/min up to 200 mL/min; 440 mL/min on L Channel |
Product Overview
The NanoAssemblr Ignite+ expands the capabilities of Ignite with increased flow rates of up to 200 mL/min pre-dilution and volumes of up to 60 mL, enabling larger preclinical and early process development studies.
NanoAssemblr Ignite also simplifies scale-up by maintaining the same critical process parameters (CPPs) as the NanoAssemblr Blaze and GMP System. Using the NxGen 500 microfluidic mixer which is also used in larger systems ensures consistent CQAs as you transition to clinical development and manufacturing while maintaining the familiar workflow of Ignite.
Larger volumes enable the incorporation of downstream process development including tangential flow filtration (TFF) at the earliest stages of preclinical development and expand efficacy and toxicity testing for large-cohort small-animal and larger animal studies including non-human primates (NHPs).
Ignite+ for Seamless Transfer of Manufacturing Processes
Establishing new specifications for CPPs including total flow rate (TFR) for large-scale preclinical and clinical systems is critical for successful scale-up. Perform these studies at the bench scale, enabling the direct protocol transfer of formulation and process parameters to larger systems, new teams or manufacturing facilities. This ensures CQAs are maintained across scales, saving time and resources while reducing risk during technology transfer.
- Demonstration video
- Benefits
- Applications
- Accessories
Demonstration video
Benefits
Simple scalability
The NanoAssemblr platform models unit operations and scalable process parameters across all systems, allowing for straightforward scale-up towards clinical development and commercial manufacture.
Fast, intuitive workflows
Ignite lowers the barrier to developing genomic medicines by providing a simple, fast and easy-to-use platform with familiar workflows, easing technology transfer and simplifying scale-up.
Reproducibility and reliability
Consistent microfluidic design ensures that environmental, user and batch variability is negligible, providing confidence and support for your drug development activities.
Applications
Gene delivery via high in vivo cell transfection efficiency
Nanoparticle design
Therapeutic drug and Vaccine development
Lipid nanoparticles formulation
Liposome encapsulation
Polymeric nanoparticles
Accessories
Cartridges
NanoAssemblr Ignite cartridges feature NxGen microfluidic technology that allows scale-up through a single mixer from mL/min to L/h. No priming or cleaning required. Automated in-line dilution and compatible with a wide range of solvents.
GenVoy-ILM lipid mix
GenVoy-ILM is an ionizable cationic lipid mix that enables the rapid and easy production of RNA-loaded lipid nanoparticles (LNPs) using the NanoAssemblr®Platform. GenVoy-ILM is the simplest way to get started with LNPs – the most advanced non-viral technology for delivering nucleic acids. Applications include preclinical development of vaccines, cell therapy and gene therapy. LNPs made with the NanoAssemblr platform exhibit a unique homogeneous core structure with exceptionally consistent size within and between batches, which has been shown to be more potent than particles made by other methods.
GenVoy-ILM™ T Cell Kit for mRNA
GenVoy-ILM™ T Cell Kit for mRNA, Ignite is an off-the-shelf LNP reagent mix optimized for the delivery of messenger RNA (mRNA) or Cas9 mRNA/sgRNA into activated human primary T cells.
Heating Package
The heating package empowers users to heat and keep their formulations in syringes at temperature when operating the Ignite.
Related products
NanoAssemblr Ignite
NanoAssemblr Ignite uses exclusive NxGen microfluidic mixing technology to allow commercial scale manufacturing of nanomedicines through a single mixer.
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NanoAssemblr Blaze
NanoAssemblr Blaze is designed to formulate nanomedicine batches from 10mL to 1L, necessary for advanced preclinical studies.
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NanoAssemblr Spark
NanoAssemblr Spark enables the manufacture of ultra-low nanoparticle volumes between 25 – 250 μL in less than 10 seconds, which is ideal for low-cost formulation of scarce materials.
Find out moreProduct Enquiry
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