NanoAssemblr Ignite+

NanoAssemblr Ignite+ builds on the features of Ignite with additional capabilities, enabling small-scale de-risking of large-scale systems and initiating process development activities using simple, low-volume workflows.

NanoAssemblr Ignite+

NanoAssemblr Ignite+ builds on the features of Ignite with additional capabilities, enabling small-scale de-risking of large-scale systems and initiating process development activities using simple, low-volume workflows.

Manufacturer Precision Nanosystems
Product Series NanoAssemblr platform
Measurement principle Emulsion and Liposome Processing
Application Nanoparticle formulation
Temperature controlUp to 65 °C
Formulation Volume60 mL non-diluted, up to 90 mL diluted
Flow Rate0.1 mL/min up to 200 mL/min; 440 mL/min on L Channel

Product Overview

The NanoAssemblr Ignite+ expands the capabilities of Ignite with increased flow rates of up to 200 mL/min pre-dilution and volumes of up to 60 mL, enabling larger preclinical and early process development studies.

NanoAssemblr Ignite also simplifies scale-up by maintaining the same critical process parameters (CPPs) as the NanoAssemblr Blaze and GMP System. Using the NxGen 500 microfluidic mixer which is also used in larger systems ensures consistent CQAs as you transition to clinical development and manufacturing while maintaining the familiar workflow of Ignite.

Larger volumes enable the incorporation of downstream process development including tangential flow filtration (TFF) at the earliest stages of preclinical development and expand efficacy and toxicity testing for large-cohort small-animal and larger animal studies including non-human primates (NHPs).

Ignite+ for Seamless Transfer of Manufacturing Processes

Establishing new specifications for CPPs including total flow rate (TFR) for large-scale preclinical and clinical systems is critical for successful scale-up. Perform these studies at the bench scale, enabling the direct protocol transfer of formulation and process parameters to larger systems, new teams or manufacturing facilities. This ensures CQAs are maintained across scales, saving time and resources while reducing risk during technology transfer.

  • Demonstration video
  • Benefits
  • Applications
  • Accessories

Demonstration video

Benefits

Simple scalability
The NanoAssemblr platform models unit operations and scalable process parameters across all systems, allowing for straightforward scale-up towards clinical development and commercial manufacture.

Fast, intuitive workflows
Ignite lowers the barrier to developing genomic medicines by providing a simple, fast and easy-to-use platform with familiar workflows, easing technology transfer and simplifying scale-up.

Reproducibility and reliability
Consistent microfluidic design ensures that environmental, user and batch variability is negligible, providing confidence and support for your drug development activities.

Applications

Gene delivery via high in vivo cell transfection efficiency
Nanoparticle design
Therapeutic drug and Vaccine development
Lipid nanoparticles formulation
Liposome encapsulation
Polymeric nanoparticles

Accessories

Cartridges

NanoAssemblr Ignite cartridges feature NxGen microfluidic technology that allows scale-up through a single mixer from mL/min to L/h. No priming or cleaning required. Automated in-line dilution and compatible with a wide range of solvents.

 

GenVoy-ILM lipid mix

GenVoy-ILM is an ionizable cationic lipid mix that enables the rapid and easy production of RNA-loaded lipid nanoparticles (LNPs) using the NanoAssemblr®Platform. GenVoy-ILM is the simplest way to get started with LNPs – the most advanced non-viral technology for delivering nucleic acids. Applications include preclinical development of vaccines, cell therapy and gene therapy. LNPs made with the NanoAssemblr platform exhibit a unique homogeneous core structure with exceptionally consistent size within and between batches, which has been shown to be more potent than particles made by other methods.

GenVoy-ILM™ T Cell Kit for mRNA

GenVoy-ILM™ T Cell Kit for mRNA, Ignite is an off-the-shelf LNP reagent mix optimized for the delivery of messenger RNA (mRNA) or Cas9 mRNA/sgRNA into activated human primary T cells.

 

Heating Package

The heating package empowers users to heat and keep their formulations in syringes at temperature when operating the Ignite.

 

Product Enquiry

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