NanoAssemblr Blaze

NanoAssemblr Blaze is designed to formulate nanomedicine batches from 10mL to 1L, necessary for advanced preclinical studies.

NanoAssemblr Blaze

NanoAssemblr Blaze is designed to formulate nanomedicine batches from 10mL to 1L, necessary for advanced preclinical studies.

Manufacturer Precision Nanosystems
Product SeriesNanoAssemblr platform
Measurement principleEmulsion and Liposome Processing
ApplicationNanoparticle formulation
Formulation volume10 mL to 1 L per batch

Product Overview

NanoAssemblr Blaze enables the manufacture of upto one litre of highly uniform nanoparticles for preclinical testing. The NanoAssemblr Blaze was developed to bridge the gap between nanoparticle discovery and clinical development. The dynamic volume range allows researchers to use the NanoAssemblr Blaze for nanoparticle discovery, preclinical toxicology testing and for early Chemistry, Manufacturing and Controls (CMC) studies.

The system utilises the latest microfluidic technology with continuous flow pumping through a proprietary microfluidic cartridge to produce large volumes of identical nanoparticles, between 10 mL and 1 L per batch. The process ensures the self-assembly of uniform particles with controllable and reproducible results.

The NanoAssemblr Blaze brings large batch nanoparticle studies in-house, and transfers small or lab-scale formulations seamlessly into large volumes. Nanoparticles made on the lower-volume NanoAssemblr Benchtop instrument scale seamlessly to the NanoAssemblr Blaze and show equivalent size and polydispersity in siRNA nanoparticles. With minimum process development, the NanoAssemblr Blaze accelerates the transfer of nanoparticle candidates towards clinical development.

  • Benefits
  • Applications
  • Accessories

Benefits

Particle Size Control: Combining reproducible microfluidics with precise fluid injection allows users to efficiently find and dial-in the optimal conditions for nanoparticle formation.

Efficient Drug Loading: Improved drug loading or encapsulation efficiency compared to conventional methods.

Scalable Production: The continuous flow microfluidic process can be scaled up by increasing total volume injected through a single mixer, or by employing multiple mixer in parallel without affecting the underlying conditions of nano particle synthesis. This allows formulations to be optimised at bench scales, and scaled up with little to no re-optimisation at each change in batch size.

Versatile: Suitable for creating a variety of different particles including:
• Biodegradable polymer nanoparticles (ex: PLGA)
• Amphiphilic block co-polymer micelles (ex: PEG-PLA)
• Dendrimer nanoparticles
• Polymer-drug conjugates
• Nucleic acid Lipid Nanoparticles (LNP)
• Lipsomes, Emulsions, Organic/ Inorganic Nanoparticles

Applications

Gene delivery via high in vivo cell transfection efficiency
Nanoparticle design
Drug development
Lipid nanoparticles formulation
Liposome encapsulation
Polymeric nanoparticles

Accessories

NanoAssemblr Blaze Cartridges with inline dilution

Cartridges allow for the manufacture of nanoparticles across a range of volumes. These disposable cartridges are single use and allow for formulation of a variety of nanoparticles via nanoprecipitation.

 

 

 

Product Enquiry

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