Benefits

Particle Size Control: Combining reproducible microfluidics with precise fluid injection allows users to efficiently find and dial-in the optimal conditions for nanoparticle formation.

Efficient Drug Loading: Improved drug loading or encapsulation efficiency compared to conventional methods.

Scalable Production: The continuous flow microfluidic process can be scaled up by increasing total volume injected through a single mixer, or by employing multiple mixer in parallel without affecting the underlying conditions of nano particle synthesis. This allows formulations to be optimised at bench scales, and scaled up with little to no re-optimisation at each change in batch size.

Versatile: Suitable for creating a variety of different particles including:
• Biodegradable polymer nanoparticles (ex: PLGA)
• Amphiphilic block co-polymer micelles (ex: PEG-PLA)
• Dendrimer nanoparticles
• Polymer-drug conjugates
• Nucleic acid Lipid Nanoparticles (LNP)
• Lipsomes, Emulsions, Organic/ Inorganic Nanoparticles

Applications

Gene delivery via high in vivo cell transfection efficiency
Nanoparticle design
Drug development
Lipid nanoparticles formulation
Liposome encapsulation
Polymeric nanoparticles

Accessories

NanoAssemblr Blaze Cartridges with inline dilution

Cartridges allow for the manufacture of nanoparticles across a range of volumes. These disposable cartridges are single use and allow for formulation of a variety of nanoparticles via nanoprecipitation.