Malvern Zetasizer Nano ZSP

The Malvern Zetasizer Nano ZSP is the highest performance system in the Zetasizer Nano range for high sensitivity measurements of nano particle size, zeta potential and molecular weight, protein mobility and microrheology measurements.

Malvern Zetasizer Nano ZSP

The Malvern Zetasizer Nano ZSP is the highest performance system in the Zetasizer Nano range for high sensitivity measurements of nano particle size, zeta potential and molecular weight, protein mobility and microrheology measurements.

Manufacturer Malvern
Product SeriesMalvern Zetasizer
Measurement principleDynamic Light Scattering
ApplicationNano Particle Size, Protein Crystallisation, Zeta Potential
Sample typeColloids, Nano particles, molecules, proteins, polymers
Size range0.3nm to 10 microns
AccuracyBetter than +/-2%
Sensitivity0.1mg/mL (Lysozyme)
Molecular weight980Da – 20M Da
MicrorheologyViscosity and viscoelasticity (option)
Sample concentrations0.1ppm to 40%w/v
Temperature fixed and rampingBetween 0°C - 90°C

Product Overview

The Malvern Zetasizer Nano ZSP is the highest performance system in the Zetasizer Nano range. It is particularly suitable for the characterisation of proteins where the highest sensitivity for size and zeta potential measurements are required. The measurements and capabilities of the Zetasizer Nano ZSP are exactly the same as the Nano ZS model with the added benefits of increased laser power and built-in protein calculators.

Zetasizers are the most widely used systems for Nano technology measurements for colloids, protein size and molecular weight. The Series includes a range of models which enables analysts to select the best system for their applications and budget.

Sizing of nano particles using the Zetasizer Nano ZSP is extremely simple and rapid as well as repeatable and non-destructive. This compact and versatile instrument enables high sensitivity nanoparticle characterisation and combines the measurement techniques of Dynamic Light Scattering, Static Light Scattering and Electrophoresis.

Dynamic Light Scattering (DLS) determines size by measuring the Brownian movement of particles or molecules in a solvent or buffer. This diffusion speed is converted into a size distribution using the Stokes-Einstein relationship.

Static Light Scattering is used to determine the molecular weight and the second virial coefficient which provides a measure of protein solubility.

Micro-electrophoresis is used to measure the Zeta potential of dispersions and surfaces.

  • Benefits
  • Applications
  • Accessories

Benefits

  • 0.3nm to 10 microns particle and molecular sizing plus Zeta potential and more….
  • A 10 mW He-Ne Laser increases the overall system sensitivity giving the Zeta potential sensitivity of Lysozyme of 0.1mg/ml
  • Built-in protein calculators, including protein charge, molecular conformation, second virial coefficient A 2 of macromolecules and of k D , the DLS interaction parameter (measurement of size as a function of concentration).
  • Dynamic Light Scattering (DLS) using Non-Invasive Back Scatter technology to give the highest sensitivity for the measurement of particle and molecule size. It also measures the microrheology of dilute polymer and protein solutions and protein melting points with the temperature ramping feature.
  • Micro-electrophoresis combined with Phase Analysis Light Scattering (M3-PALS) is used to measure both the zeta potential of dispersions and surface zeta potential.
  • Static Light Scattering is used to determine the molecular weight of proteins and polymers and the second virial coefficient which provides a measure of protein solubility.
  • Patented Non-Invasive Backscatter (NIBS) optics provides exceptional sensitivity to enable measurement of small (down to 980Da) molecules and samples at very low or high concentrations without dilution (0.1ppm to 40%w/v).
  • Comprehensive software. This incorporates Standard Operating Procedures (SOP), a Quality Factor to give confirmation of data quality and Expert Advice System to assist with data interpretation
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Applications

  • Shorten development time for emulsions and dispersion of nanoparticles, liposomes, colloids and protein and polymer formulations.
  • Assess and improve protein formulation stability and improve shelf life
  • Investigate zeta potential of surfaces
  • Explore protein aggregation and oligomeric state
  • Surfactant micelle characterisation using dynamic light scattering
  • Protein mobility measurement using the Diffusion Barrier Technique using 20µL sample
  • Improve ink, toner and pigment performance
  • Optimise flocculant dosage to reduce cost for water treatment
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Accessories

NanoSampler.
Automated sample delivery system for particle size measurement.

MPT-2 Automated Titrator.
Automates the measurement of size and zeta potential as a function of pH, conductivity or additive.

SV-10 viscometer
Measures viscosity for the conversion of diffusion speed to size, and electrophoretic mobility to zeta potential.

Universal ‘dip’ cell kit
A reusable solvent resistant cell for the measurement of zeta potential in aqueous and non-aqueous dispersants using polystyrene or glass cuvettes.

High concentration zeta potential cell kit
This enables the measurement of the zeta potential with little or no sample dilution. The cell has a flow configuration so can be used for stop-flow size and zeta potential measurements using an MPT-2 autotitrator.

Surface zeta potential accessory
The surface zeta potential accessory enables the measurement of the zeta potential of flat surfaces such as filter paper, silica, polymers and bone.

Disposable folded capillary cell (DTS1070)
Eliminates sample cross contamination between zeta potential measurements. This provides the accuracy of a capillary cell with the ease of use of a disposable cell. For low conductivity samples each cell can be used for hundreds of measurements.The cell can be used with the autotitrator.

 

 

 

 

 

Zetasizer Nano ZSP options

  • Flow mode: Converts the system to a chromatography size detector for SEC or FFF.
  • Optical Filters: Filters to improve the measurement of fluorescent samples,
  • Increased temperature: Temperature range extension to 120ºC
  • 21CFR part 11: software option to enable compliance with ER/ES.
  • Research software: Additional features and analysis algorithms for the specialist.
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