Malvern Zetasizer Micro V

The Malvern Zetasizer µV is a highly sensitive light scattering detector dedicated to the measurement of protein molecular size and weight.

Malvern Zetasizer Micro V

The Malvern Zetasizer µV is a highly sensitive light scattering detector dedicated to the measurement of protein molecular size and weight.

Manufacturer Malvern
Product SeriesMalvern Zetasizer
Measurement principleDynamic Light Scattering
ApplicationMolecular Weight & Size
Sample typeProteins
Particle size range0.3nm – 2µm
Accuracy+/-2%
Minimum sample volume2μL
Molecular weight as SEC detector< 1kDa – 5MDa
Accuracy+/- 5% typical
Temperature fixed and rampingbetween 2°C - 90°C.

Product Overview

The Malvern Zetasizer µV is a highly sensitive light scattering detector dedicated to the measurement of protein molecular size and weight. It incorporates both Dynamic Light Scattering (DLS) and Static Light Scattering (SLS) enabling it to be used as a chromatography detector.

The Zetasizer µV can be used as a detector with any GPC/SEC system, including Viscotek, to give molecular size and molecular weight. Alternatively, in cuvette mode, it is suitable for the detection of aggregates and for monitoring aggregate formation.

Dynamic Light Scattering (DLS) determines size by measuring the Brownian movement of particles or molecules in a solvent or buffer. This diffusion speed is converted into a size distribution using the Stokes-Einstein relationship. Static Light Scattering is used to determine the molecular weight and the second virial coefficient which provides a measure of protein solubility.

Zetasizers are the most widely used systems for Nano technology measurements for colloids, protein size and molecular weight. The Series includes a range of models which enables analysts to select the best system for their applications and budget.

  • Benefits
  • Applications

Benefits

  • Switch in seconds from chromatography detector to cuvette mode.
  • Sensitivity – 0.1mg/mL 15kDa protein (Lysozyme).
  • Only 2µL sample required in cuvette mode.
  • Automated temperature ramping for melting point determination.
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Applications

  • Determine protein oligomeric state and the level of protein aggregation
  • Perform conjugate analyses to determine molecular weight and composition of complexes
  • Predict stability from the temperature required to denature the protein.
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