Malvern NanoSight NS300

Malvern NanoSight NS300 provides high resolution size distribution and concentration measurements for individual nanoparticles while a fluorescence mode allows differentiation of fluorescing particles.

Malvern NanoSight NS300

Malvern NanoSight NS300 provides high resolution size distribution and concentration measurements for individual nanoparticles while a fluorescence mode allows differentiation of fluorescing particles.

Manufacturer Malvern
Product SeriesMalvern NanoSight
Measurement principleNano Particle Tracking
ApplicationExosome Tracking, Nano Particle Size, Nano Particle Tracking & Count
Sample typeExosomes, Nanoparticles
Particle size range10nm to 2000nm
Laser wavelengths405nm (Violet), 488nm (Blue), 532nm (Green), 642nm (Red)
Low sample volume0.3ml
Concentrationto 10 9 particles per mL
Temp Control-5 to 55°C
FluorescenceMotorised 6 place filter wheel with choice of filters

Product Overview

The Malvern NanoSight NS300 uses unique Nanoparticle Tracking Analysis (NTA) technology to detect and visualise populations of nanoparticles (10nm to 2000nm) on a particle by particle basis. The technique uses the properties of both light scattering and Brownian motion to calculate particle size and concentration.

The random movement of each particle in a fluid (Brownian motion) is tracked by capturing the light scattered by the particles when illuminated by a laser. A digital camera together with specially designed software capture the light scattered by the particles and track their motion frame by frame. The rate of movement is related to particle size, which is calculated by using the Stokes-Einstein equation to give hydrodynamic diameter. Labelled or naturally fluorescent particles can also be detected with a choice of laser wavelengths and a motorised fluorescence disc.

NTA provides high resolution particle size distribution, concentration, protein aggregation and viscosity results, independent of particle density and refractive index. Events such as aggregation and dissolution can be monitored as they occur.

The software is specifically designed to meet the needs of both new and experienced users. Standard Operating Procedures (SOPs) can be easily set up as well as customised reporting and full access to raw data for a more in-depth analysis of results.

  • Benefits
  • Applications
  • Accessories

Benefits

  • Particle by Particle analysis for high resolution size and concentration
  • Visual validation delivers further confidence for the results
  • Fluorescence mode provides detection of labelled particles
  • Monitor real time events
  • Easy to use intuitive software
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Applications

Development of drug delivery systems

  • Viral vaccine research
  • Nano-toxicology and biomarker detection
  • Protein aggregation research
  • Extracellular vesicle characterisation for various disease state studies
  • Characterisation of exosomes and microvesicles

 

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Accessories

Syringe Pump for improved sampling
The Syringe pump for the NanoSight NS300 has been designed to enable users to perform sample analysis at a constant flow rate. Key benefits include:

  • Flow controlled detection of fluorescent signal from labelled particles
  • Automated multiple analysis of low concentration samples
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