Product Overview

The Fluidity ONE-M enables the quantification of protein interactions in complex backgrounds such as biological systems or serum.

Using proprietary Microfluidic Diffusional Sizing (MDS) technology, which is based on the relationship between size and diffusion rate, the Fluidity ONE-M can determine the binding affinity (KD) as well as the hydrodynamic radius or molecular size (Rh), concentration and Stoichiometry from a single experiment. 

Within one hour, binding affinity, concentration and stoichiometry measurements can occur directly in serum, eliminating time-consuming purification steps and increasing sensitivity by minimising risk of dilution effects.

This unique combination of information can help scientists determine how strongly proteins are binding, how many protein molecules are binding at a time and whether the protein is binding to its target or to something unexpected. MDS is used to determine the binding affinity between proteins and their binding partners; whether they are aptamers, lipids, DNA, small molecules or other proteins.

Contact us to discuss options for using MDS with your own samples, or select from standard assays already available. These include: Affinity and concentration determination (SARS-CoV-2 variants, SARS CoV-1, other coronaviruses); Rapid affinity-based virus neutralisation assay and Protein labelling.