EXODUS T-2800 Exosome Isolation For GMP Manufacturing

EXODUS T-2800 is a high efficiency exosome isolation system for large-scale GMP manufacturing. 

EXODUS T-2800 Exosome Isolation For GMP Manufacturing

EXODUS T-2800 is a high efficiency exosome isolation system for large-scale GMP manufacturing. 

Manufacturer EXODUS
Product Series EXODUS
Measurement principle Purification
Application Exosome isolation, Exosome Tracking
Sample type Plasma, urine, saliva, cerebrospinal fluid, tears, aqueous humor, synovial fluid, tissue, cell culture medium, bacterial culture medium, cell-derived vesicle, plant, etc
Isolation principleDual-Membrane Nanofiltration System
Processing volumes1-10 L
Processing speed1-2 L/h
Protein removal efficiency>99%
Temperature control2-8°C

Product Overview

EXODUS T-2800 is a large-scale, fully automatic label-free exosome isolation system that integrates sample pre-processing, exosome isolation, and collection.

This system is designed to support the industrial-scale, automated production of high-purity and high-yield exosomes, ensuring stability and compliance with Good Manufacturing Practices (GMP).

EXODUS is a highly efficient exosome isolation method that uses ultrasonic nano-filtration technology. A dual-membrane nanofiltration system integrates periodic negative pressure oscillation (NPO) and double-coupled ultrasonic harmonic oscillations (HO). Exosomes are precisely intercepted while free nucleic acid and protein impurities are removed from the sample, resulting in the extraction of ultra-pure exosomes.

EXODUS presents several advantages over conventional membrane separation methods enabling high-quality intact exosomes can be quickly and easily isolated with excellent yield and purity from various biofluids. It achieves clog-free ultra-fast purification of exosomes in high yield while eliminating contaminants including cell-free nucleic acids and lipoproteins which interfere with exosomal biomarker interpretation.

The EXODUS exosome isolation system outperforms other isolation techniques in speed, purity and yield offering a more efficient method to help drive new discoveries in biomedical research and translation. Isolated exosomes can be used for characterisation, screening of disease markers, exosome drug delivery, treatment, and regenerative medicine.

  • Demonstration video
  • BENEFITS
  • Applications
  • FEEDBACK

Demonstration video

 

BENEFITS

Three-in-one
Three functions are integrated into one instrument: sample pre-processing, isolation, and automatic recovery, all featuring simple and user-friendly operations.

Outstanding purity and yield
Protein removal efficiency >99%, with particle-to-protein ratio >5×108 particles/ug protein; exosome concentration >1×1011 particles/mL.

Reliable quality
The isolated exosomes are sterile and free from endotoxins, complying with established safety limits; it removes >99% of proteins from culture media, ensuring enhanced safety for downstream applications.

Stable and controllable
Fully automatic workflow that ensures batch-to-batch stability, full-process status monitoring, and intelligent handling.

Safe and compliant
A single-use approach: fully enclosed consumables that meet pharmacopeial standards, i.e., sterile and endotoxin-free products. The system and software
comply with GMP and 21 CFR part 11 requirements, respectively.

Applications

  • Drug delivery
  • Exosome therapeutics
  • Regenerative medicine
  • Early diagnosis

Publications 

NO. Title Journal
01 Exosome Detection via the Ultrafast-Isolation System: EXODUS Nature Methods
02 UPCARE: Urinary Extracellular Vesicles-Derived Prostate Cancer Assessment for Risk Evaluation Journal of Extracellular Vesicles
03 Discovering the Secret of Diseases by Integrated Tear Exosomes Analysis via Rapid-isolation System: ITEARS ACS Nano
04 Robust Acute Pancreatitis Identification and Diagnosis: RAPIDx ACS Nano
05 Interaction Network of Extracellular Vesicles Building Universal Analysis via Eye Tears: TNEBULA Science Advances
06 Sensitive Small Extracellular Vesicles Associated CircRNAs Analysis Combined with Machine Learning for Precision Identification of Gastric Cancer  

Chemical Engineering Journal

07 Quantitative Metabolic Analysis of Plasma Extracellular Vesicles for the Diagnosis of Severe Acute Pancreatitis Journal of Nanobiotechnology
08 Lipidomic Identification of Urinary Extracellular Vesicles for Non-Alcoholic Steatohepatitis Diagnosis Journal of Nanobiotechnology
09 Metabolomic Investigation of Urinary Extracellular Vesicles for Early Detection and Screening of Lung Cancer Journal of Nanobiotechnology
10 The Genetic Source Tracking of Human Urinary Exosomes PNAS
11 Identification and Detection of Plasma Extracellular Vesicles-derived Biomarkers for Esophageal Squamous Cell Carcinoma Diagnosis  

Biosensors & Bioelectronics

12 Audible Acoustic Wave Promotes EV Formation and Secretion from Adherent Cancer Cells via Mechanical Stimulation ACS Applied Materials & Interfaces
13 Identification of Circulating Extracellular Vesicle Long RNAs as Diagnostic Biomarkers for Patients with Severe Acute Pancreatitis  

Clinical and Translational Medicine

14 Prediction of Response to Chemoradiotherapy by Dynamic Changes of Circulating Exosome Levels in Patients with Esophageal Squamous Cell Carcinoma  

International Journal of Nanomedicine

15 Investigating The Proliferative Inhibition of HepG2 Cells by Exosome-like Nanovesicles Derived from Centella Asiatica Extract Through Metabolomics  

Biomedicine & Pharmacotherapy

16 Gut Subdoligranulum Variabile Ameliorates Rheumatoid Arthritis by Promoting TSG-6 Synthesis from Joint Cells Frontiers in Immunology
17 Metabolomic Analysis of Exosomal-Markers in Esophageal Squamous Cell Carcinoma Nanoscale
18 Metabolic Signatures of Tear Extracellular Vesicles Caused by Herpes Simplex Keratitis Ocular Surface
19 Sensitive Electrochemical Biosensor for Rapid Detection of sEV-MiRNA Based Turbo-Like Localized Catalytic Hairpin Assembly  

Analytica Chimica Acta

20 Isolation of Exosome Nanoparticles from Human Cerebrospinal Fluid for Proteomic Analysis ACS Applied Nano Materials
21 Human Umbilical Cord Mesenchymal Stem Cells Inhibit Liver Fibrosis via The MicroRNA-148a-5p/SLIT3 Axis International Immunopharmacology
22 Patient-derived Induced Pluripotent Stem Cells with a MERTK Mutation Exhibit Cell Junction Abnormalities and Aberrant Cellular Differentiation Potential  

World Journal of Stem Cells

23 Assessing Alzheimer’s Disease via Plasma Extracellular Vesicle–Derived mRNA Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
24 Efficient Preparation of High-purity and Intact Mesenchymal Stem Cell–derived Extracellular Vesicles Analytical and Bioanalytical Chemistry
25 Plasma-derived Exosomal miR-25-3p and miR-23b-3p as Predictors of Response to Chemoradiotherapy in Esophageal Squamous Cell Carcinoma Technology in Cancer Research & Treatment
26 Comparative Investigation of Exosome Extraction from rat bone Marrow Mesenchymal Stem Cells Using Three Different Methodologies  

Electrorhoresis

27 Isolation of Small Extracellular Vesicles from a Drop of Plasma via EXODUS and Their Fingerprint Proteomics Profiling by MALDI-TOF MS  

Biosensors & Bioelectronics: X

28 Application of EXODUS System Combined with Allosteric DNA Nanoswitches in the Detection of miR-107 Among Plasma Exosomes of Parkinson′s Disease Patients  

Chinese Journal of Preventive Medicine

 

 

FEEDBACK

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