Molecular size, KD, Concentration and stoichiometry from a single experiment

03 Dec, 2021 | Newsletters
Molecular size, KD, Concentration and stoichiometry from a single experiment

The new Fluidity One-M system offers the latest technology for the purpose of quantifying and characterising protein interactions – even in complex backgrounds or with challenging targets, in a single experiment.

Fluidity One-M benefits: Uses microfluidic diffusional sizing (MDS) technology to measure changes in molecular size (hydrodynamic radius) as binding events occur Enables development of customised protocols to study a wide range of interactions – typical run time 35 minutes for 24 datapoints to determine KD Eliminates risk of binding artefacts or other surface constraints – measure directly in solution – no surface immobilisation Minimises consumption of precious samples – 3.5 μL per datapoint (application dependent), 50-80 μL to determine KD  


This collection of must-watch webinars cover a range of topics from measuring antibody affinity in serum to monitoring of SMALP nanodisc formation, to quantifying the stoichiometry and binding affinity of protein–protein interactions in complex backgrounds.  All webinars are available to view on demand  

Immune responses to SARS-CoV-2
In this webinar, Professor Akiko Iwasaki will discuss immune responses in COVID-19 patients with moderate and severe disease. She will compare viral load, immune phenotype and cytokines that are predictive of mortality, and discuss signatures of cytokines and growth factors that associate with recovery vs. disease exacerbation.

Safe, Rapid and Variant-Specific Affinity-Based Virus-Neutralization Assays
A new type of rapid assay is discussed based on quantifying protein interactions and provides functional insights equivalent to the gold standard cell-based neutralization assay by measuring the affinity, concentration, and neutralization potential of antibodies against the SARS-CoV-2 spike protein directly in serum.   
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