MEASURE SECONDARY STRUCTURE WHERE OTHERS CAN’T WITH AQS3PRO
17 Nov, 2021 | Newsletters

Understand Protein Behaviour, Conformational Stability, and Aggregation Pathways Microfluidic Modulation Spectroscopy (MMS) is a powerful new IR-based analytical technique that provides direct measurement of previously undetectable changes in protein structure. MMS overcomes many of the limitations of traditional spectroscopy-based technologies (e.g. FTIR & CD) with ultrasensitive, highly reproducible, automated structural measurements of proteins and other biomolecules. It can be used for a wide range of applications from formulation development of mAb-based biotherapeutics to robust measurements of ADCs, AAVs, and mRNA. Key benefits of the AQS3pro: Ability to measure wide range of native sample concentrations from <0.1 mg/ml to >200 mg/ml Fully automated sample-handling, with both 24 and 96 well plate formats Real-time background subtraction eliminates need to dialyse samples, no labels required Detection of <2% change in secondary structure even at low concentrations Advanced onboard data analytics enabling rapid and robust data interpretation and reporting CONTACT US FOR A DEMO TODAY What is Microfluidic Modulation Spectroscopy (MMS)? ![]() WATCH THIS SHORT INTRO This short video introduces the AQS3pro – A Microfluidic Modulation Spectroscopy Platform for Protein Characterisation. The AQS3™pro measures protein and peptide structure, using Microfluidic Modulation Spectroscopy (MMS). ![]() GET YOUR FREE E-BOOK This eBook introduces you to MMS which provides direct measurement of previously undetectable changes in protein structure. Measure aggregation, quantitation, stability, structure, and similarity within a single sample or between samples. using an automated platform. ![]() AQS3Pro Powered by Microfluidic Modulation Spectroscopy MMS is a unique, patented technology in which the sample (protein) solution and a matching buffer reference stream are automatically introduced into a microfluidic flow cell. The two fluids are rapidly modulated (e.g. 1-5 Hz) across the laser beam path to automatically perform background subtraction, dramatically improving measurement precision, accuracy, and signal-to-noise. DOWNLOAD A COPY OF THE BROCHURE Discover how MMS can strengthen your bioanalytical tool kit by providing critical insight through all phases of protein-based drug development. Watch the latest recorded webinars now! ![]() WATCH THIS WEBINAR Dr. Lucy Liu of Pfizer demonstrates MM-IR secondary structure analysis of therapeutic monoclonal antibodies (mAb) and shows higher sensitivity and repeatability for low concentration samples over FTIR. ![]() WATCH THIS WEBINAR Dr. Shawn Owen discusses advanced characterisation techniques including MMS to assess biophysical properties of antibody-drug conjugates (ADCs). CONTACT US FOR MORE INFORMATION |