MEASURE SECONDARY STRUCTURE WHERE OTHERS CAN’T WITH AQS3PRO
17 Nov, 2021 | Newsletters
|Understand Protein Behaviour, Conformational Stability, and Aggregation Pathways|
Microfluidic Modulation Spectroscopy (MMS) is a powerful new IR-based analytical technique that provides direct measurement of previously undetectable changes in protein structure.
MMS overcomes many of the limitations of traditional spectroscopy-based technologies (e.g. FTIR & CD) with ultrasensitive, highly reproducible, automated structural measurements of proteins and other biomolecules. It can be used for a wide range of applications from formulation development of mAb-based biotherapeutics to robust measurements of ADCs, AAVs, and mRNA.
Key benefits of the AQS3pro:
Ability to measure wide range of native sample concentrations from <0.1 mg/ml to >200 mg/ml Fully automated sample-handling, with both 24 and 96 well plate formats Real-time background subtraction eliminates need to dialyse samples, no labels required Detection of <2% change in secondary structure even at low concentrations Advanced onboard data analytics enabling rapid and robust data interpretation and reporting
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What is Microfluidic Modulation Spectroscopy (MMS)?
WATCH THIS SHORT INTRO
This short video introduces the AQS3pro – A Microfluidic Modulation Spectroscopy Platform for Protein Characterisation. The AQS3™pro measures protein and peptide structure, using Microfluidic Modulation Spectroscopy (MMS).
GET YOUR FREE E-BOOK
This eBook introduces you to MMS which provides direct measurement of previously undetectable changes in protein structure. Measure aggregation, quantitation, stability, structure, and similarity within a single sample or between samples. using an automated platform.
AQS3Pro Powered by Microfluidic Modulation Spectroscopy
MMS is a unique, patented technology in which the sample (protein) solution and a matching buffer reference stream are automatically introduced into a microfluidic flow cell. The two fluids are rapidly modulated (e.g. 1-5 Hz) across the laser beam path to automatically perform background subtraction, dramatically improving measurement precision, accuracy, and signal-to-noise. DOWNLOAD A COPY OF THE BROCHURE
Discover how MMS can strengthen your bioanalytical tool kit by providing critical insight through all phases of protein-based drug development. Watch the latest recorded webinars now!
WATCH THIS WEBINAR
Dr. Lucy Liu of Pfizer demonstrates MM-IR secondary structure analysis of therapeutic monoclonal antibodies (mAb) and shows higher sensitivity and repeatability for low concentration samples over FTIR.
WATCH THIS WEBINAR
Dr. Shawn Owen discusses advanced characterisation techniques including MMS to assess biophysical properties of antibody-drug conjugates (ADCs).
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