How benign moles can switch to cancerous melanoma

25 Feb, 2022 | Newsletters
How benign moles can switch to cancerous melanoma
 Did you know that in Australia, one person dies from melanoma every five hours? Melanoma is often referred to as ‘Australia’s National Cancer’ and is the third most common cancer in Australia. Most are caused by prolonged and repeated exposure to UV radiation in sunlight, but there are some melanomas that are not sun related, eg, Bob Marley famously died of an acral lentiginous melanoma on his toe in 1981. Melanocyte cells produce melanin to protect the deeper layers of skin but when unregulated or uncontrolled, melanomas can develop, metastasise and become life threatening. A team of researchers working at University of California, San Francisco, in collaboration with The Huntsman Institute, Utah aimed to investigate the mechanisms by which a benign mole (nevus) can switch from being stable melanocyte cells to cancerous melanoma cells.  

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The Role of HECTD2 Ubiquitin Ligase in Melanoma Progression  
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