Fluidity ONE-W Serum to study binding affinity of antibodies to virus proteins in serum

The ability to accurately characterise the immune response against SARS-CoV-2 is of vital importance in managing the current COVID-19 pandemic. Measuring antibody affinity under physiologically relevant conditions in complex mixtures like serum remains challenging but is critically important to furthering our understanding of the immune response and protection window in patients and vaccinated individuals.

Using Microfluidic Diffusional Sizing (MDS), the new Fluidity ONE-W from Fluidic Analytics was used to characterise an anti-spike S1antibody by measuring its binding affinity to the receptor binding domain (RBD) of the SARS-CoV-2 spike protein directly in serum.

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