EXODUS offers automatic, label free, highly efficient exosome isolation and purification

The EXODUS automatic exosome isolation system represents an advanced technological approach for laboratories engaged in extracellular vesicle (EV) research, particularly those focused on exosomes. Exosomes, nanometer-scale EVs with key roles in cell-cell communication, have gained prominence due to their potential as biomarkers for disease diagnostics and as vehicles for therapeutic delivery. Yet, traditional methods for exosome isolation—such as ultracentrifugation, precipitation, and size-exclusion chromatography—pose challenges, including low yield, variable purity, labour-intensive, and susceptibility to sample degradation which limits reproducibility and scalability.
The EXODUS automatic exosome isolation system minimises manual handling, reducing variability and enabling consistent, high-purity yields across a range of biological fluids, including serum, plasma, urine, and cell culture media. Such precision facilitates the preservation of exosomal structural integrity and bioactive molecules, ensuring reliability in downstream applications, including molecular profiling and drug delivery studies.
EXODUS has been developed using a dual-membrane nanofiltration system that integrates periodic negative pressure oscillation (NPO) and double-coupled ultrasonic harmonic oscillations (HO). The exosomes are precisely intercepted by nanoporous membrane, while free nucleic acid and protein impurities are removed from the sample, resulting in the efficient purification and enrichment of exosomes.
The EXODUS system is well-suited for labs aiming to scale up exosome research while maintaining rigorous standards in quality and reproducibility. EXODUS eliminates challenges associated with traditional ultracentrifugation, making exosome isolation more accessible and efficient. Researchers adopting the EXODUS system can expect enhanced workflow efficiency and the capacity to drive new discoveries in the rapidly expanding field of EV research.
Reference:
Chen, Y., Zhu, Q., Cheng, L. et al. Exosome detection via the ultrafast-isolation system: EXODUS. Nat Methods 18, 212–218 (2021). https://doi.org/10.1038/s41592-020-01034-x
For more information, please contact us.