Surface Plasmon Resonance
Surface Plasmon Resonance (SPR) is an established method to monitor label-free biomolecular interactions in liquids. However, the SPR 200 can deliver well beyond the traditional SPR biophysical measurements of kinetics and equilibrium constants. This highly versatile system can also characterise optical constants and thicknesses of nanoscale structures such as Langmuir-Blodgett monolayers and bio-films.
Click here to contact usThis innovative system uses a wide angular scan range to produce a complete SPR curve. This allows the simultaneous characterisation of surfaces in gas and/or liquid so that a surface can be checked before sample injection.
Contamination-free SPR
The unique design of the sensor plate holder and easy “drop-in” action means there is very little risk of contamination. Sensor plates can be modified outside the instrument prior to analysis. This enables the user to create a huge range of custom-modified surfaces. The removable sensor system allows combining SPR data with other surface measurements such as topography, wettability, chemical composition, photochemical processes swelling and adsorption.
The proprietary optical gel does away with the need for messy and potentially contaminating index-matching oil. It enables convenient access to the removable flow cell resulting is a contamination-free environment.
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Nano-scale film measurements
An incident beam of p-polarized light strikes an electrically conducting gold layer at the interface of a glass sensor (high Refractive Index) and an external medium with low RI (gas or liquid).
At a given angle, the excitation by light of surface plasmons existing at the interface generates a “resonance” of these surface plasmons – resulting in a reduced intensity of the reflected light.
A slight change at the interface (e.g. a change in refractive index or nanoscale film thickness) will lead to a change in SPR signal – allowing precise measurements of nanoscale film properties as well as surface molecular interactions.
Other design features
- Dual measurement channels for in-line referencing and/or duplicate measurements
- Support for a second laser wave length, for simultaneous determination of RI and thickness
- High-accuracy sensogram (kinetic) measurements
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